The Buffalo Bills (6-4) and New Orleans Saints (5-5) wrap up Thanksgiving’s tripleheader in Week 12. Kickoff is set for 8:20 p.m. ET at Caesars Superdome. Below, we look at the Bills vs. Saints odds and lines, and make our best NFL picks, predictions and bets.
Buffalo is coming off a 41-15 beatdown at home by the Indianapolis Colts and RB Jonathan Taylor, who set an Indy record with 5 touchdowns. The Bills, who were 7-point favorites, fell out of first place in the AFC East and are 2-3 in their last five games.
New Orleans enters on a three-game slide, recently falling as a 3-point underdog at the Philadelphia Eagles 40-29 in Week 11. Since QB Jameis Winston suffered a season-ending ACL injury in a 36-27 win over the Super Bowl champion Tampa Bay Buccaneers in Week 8, the Saints are 0-3 SU/1-2 ATS with QB Trevor Siemian under center.
Also see: All Week 12 odds and lines
Bills at Saints odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 12:50 p.m. ET.
- Money line: Bills -260 (bet $260 to win $100) | Saints +205 (bet $100 to win $205)
- Against the spread (ATS): Bills -5.5 (-117) | Saints +5.5 (-103)
- Over/Under (O/U): 45.5 (O: -108 | U: -112)
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Betting stats:
- ATS: Bills 5-4-1 | Saints 5-5
- O/U: Bills 5-5 | Saints 6-4
Bills at Saints key injuries
Bills
- None
Saints
- DE Marcus Davenport (shoulder) questionable
- RB Alvin Kamara (knee) questionable
- LT Terron Armstead (knee) questionable
- RB Mark Ingram (knee) questionable
- OT Ryan Ramczyk (knee) questionable
- TE Adam Trautman (knee) IR-out
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Bills at Saints odds, lines, predictions and picks
Prediction
Bills 30, Saints 21
Money line
PASS. The Bills’ -260 price is too steep. If you really want to back the Buffalo money line, don’t wager more than a half unit.
Against the spread
BUFFALO -5.5 (-117) is the way to go. The Bills, who haven’t lost back-to-back regular-season games since Week 5 and Week 6 of last season, have to be fuming after the spanking by the Colts.
The Buffalo defense leads the league with the fewest total yards allowed per game (283.7) and ranks second in passing yards (181.8) and points (17.6) allowed per game.
The New Orleans offense is 24th in yards per game (321.3), 26th in passing yards per game (203.4) and 14th in points per game (25.1).
Those numbers don’t bode well for the home team against a Buffalo squad that will be overly focused on getting back on track.
Over/Under
OVER 46.5 (-112) is the STRONGEST PLAY – 1½ times your usual wager.
The Over is 4-0 in the Saints’ last four games and 6-1 in their last seven.
The Over is 4-2 in the Bills’ last six games, including 2-0 in the last two. Plus, the Buffalo offense averages 29.5 points per game to rank second in the NFL.
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.
| JOHNNY’S RECORD | W-L | SP | ROI |
| SINCE JULY 8 | 77-52 | 32-18 | +23.42 |
| NFL 2021 | 12-10 | 6-4 | +0.836 |
| *–SP: Strongest plays; ROI: Return on investment | |||
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