Buffalo Bills vs. Detroit Lions odds predictions pick betting line spread

Buffalo Bills at Detroit Lions odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at Detroit Lions odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (10-3) take on the Detroit Lions (12-1) Sunday in Week 15. Kickoff from Ford Field is set for 4:25 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Lions odds, and make our expert NFL picks and predictions.

The Bills were marched out of town by the LA Rams in a 44-42 defeat in Week 14. They made a late push, down 38-21 in the fourth quarter, but it wasn’t enough. QB Josh Allen had a huge game, going 22-for-37 for 342 yards, 3 TDs and 0 INTs while rushing 10 times for 82 yards and 3 more TDs.

The Lions won their 11th straight in a 34-31 win over the Green Bay Packers Dec. 5. QB Jared Goff was 32-for-41 for 283 yards, 3 TDs and 1 INT. He spread the ball around to 6 different receivers that had 5 grabs apiece. WR Tim Patrick introduced himself with a 6-43-2 evening.

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Bills at Lions odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 5:42 p.m. ET.

Moneyline (ML): Bills +120 (bet $100 to win $120) | Lions -145 (bet $145 to win $100)
Against the spread (ATS): Bills +2.5 (-110) | Lions -2.5 (-110)
Over/Under (O/U): 54.5 (O: -110 | U: -110)

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Bills at Lions key injuries

Bills

CB Rasul Douglas (knee) out
S Damar Hamlin (back, ribs) questionable
TE Dalton Kincaid (knee) questionable
S Taylor Rapp (neck, shoulder) questionable

Lions

LB Trevor Nowaske (concussion) out

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Bills at Lions picks and predictions

Prediction

Bills 24, Lions 20

Moneyline

I’m taking Buffalo here. They’re getting Kincaid back, despite his questionable tag, and WR Keon Coleman (wrist) returns as well. Allen is playing on another level right now as he seeks his first MVP award. The Lions have been off for 10 days and don’t really need to be as hungry at 12-1.

Take the BILLS +120.

Against the spread

I’d consider the Bills’ side of the spread if it swells to 3.5 by kickoff. There’s no point in taking it here, though. Instead, give me JOSH ALLEN ANYTIME TOUCHDOWN (+115). He has one in 4 straight games and 6 during that span.

Over/Under

I like the Under here in a defensive struggle. The Lions are 2-3-1 O/U in their last 6. Buffalo is 4-0-1 in its last 5, but that’s thanks to scoring 30+ points in 7 straight games. That’s not happening here.

Take the UNDER 54.5 (-110).

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Buffalo Bills at Detroit Lions odds, picks and predictions

Analyzing Thanksgiving Day’s Buffalo Bills at Detroit Lions odds and lines, with expert NFL picks, predictions and best bets.

The Buffalo Bills (7-3) and Detroit Lions (4-6) open Thanksgiving’s triple-header with the early game from Ford Field at 12:30 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the Bills vs. Lions odds, and make our expert NFL picks and predictions.

QB Josh Allen and the Bills beat the Cleveland Browns at Ford Field 31-23 last week, covering the spread as 7.5-point favorites. The game was moved to Detroit due to a snowstorm in Western New York. Allen threw for 197 yards with a TD in the victory.

The Lions, who were 3-point underdogs, went on the road and beat the New York Giants 31-18 in Week 11. Detroit was able to hold New York RB Saquon Barkley to 22 rushing yards on 15 carries.

If the Lions want to win this matchup, they’ll need to stop the 6-foot-5, 240-pound Allen from running and throwing all over them. It will be a challenging task for Detroit, which is 37-43-2 on Thanksgiving.

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Bills at Lions odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 11:44 p.m. ET.

Moneyline (ML): Bills -450 (bet $450 to win $100) | Lions +350 (bet $100 to win $350)
Against the spread (ATS): Bills +-9.5 (-111) | Lions +9.5 (-109)
Over/Under (O/U): 54 (O: -107 | U: -113)

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Bills at Lions key injuries

Bills

LB Tremaine Edmunds (groin) out
DE A.J. Epenesa (ankle) doubtful
C Mitch Morse (elbow, ankle) questionable
DE Greg Rousseau (ankle) out

Lions

OL Evan Brown (ankle) out
DE Charles Harris (groin) out
OL Jonah Jackson (concussion) out
CB Jeff Okudah (concussion) out
DE Joshua Paschal (knee) out
WR Josh Reynolds (back) questionable

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Bills at Lions picks and predictions

Prediction

Bills 31, Lions 17

Moneyline

PASS.

The Bills (-450) are the far better team, but it’s not smart a smart sports betting strategy to risk 4.5 times your potential profit. I could see including them in a multi-team parlay, however.

Against the spread

BET BILLS -9.5 (-111).

The Bills just played at Ford Field last week because of the Buffalo snowstorm with 56,000 strong showing up and buying tickets within 48 hours of the announced change. The Bills were comfortable in the atmosphere, and this week will be no different.

While they won’t have close to as many fans this time, the Bills will feel right at home. Allen and WR Stefon Diggs will take advantage of Lions CB Okudah missing this game. Diggs, after being upset early last week by the lack of targets vs. Cleveland, will be fed this week vs. Detroit, perfect for Thanksgiving.

BUFFALO -9.5 (-111) is my FAVORITE PLAY in this game.

Over/Under

BET UNDER 54 (-113).

What will it take for this game to get to this substantial number? Buffalo to score 40.

While it’s possible, I don’t find it likely.

Last week, the Bills racked up 31 points. On a short week, they will look to get out with no injuries, while the Lions will use RBs D’Andre Swift and Jamaal Williams to shorten the game and keep the Bills offense off the field.

With limited drives being the goal, the game will be a slow paced, and the scoring is not likely to reach this number. While the game will be close, I don’t see it going Over 54. Therefore, UNDER 54 (-113) is the play.

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Buffalo Bills at Detroit Lions odds, picks and prediction

Analyzing the Buffalo Bills at Detroit Lions preseason Week 1 matchup, with NFL odds, lines, picks, predictions and best bets.

The Buffalo Bills are in the Motor City Friday night for their preseason opener against the Detroit Lions. Kickoff will be at 7 p.m. ET at Ford Field. Below, we look at the Bills at Lions odds and lines, and make our best NFL picks, predictions and bets.

The Bills will take a more cautious approach to this game than the Lions. Buffalo is not expected to play the majority of its starters, including QB Josh Allen. Lions starters will play about a quarter, so this will be our first look at QB Jared Goff with his new team.

Buffalo is coming off a season in which it reached the AFC Championship Game, only to lose to the Kansas City Chiefs. Allen was a Pro Bowler and one of the best quarterbacks in football, getting rewarded with a massive extension this offseason.

The Lions are currently in a rebuild after trading away QB Matthew Stafford for Goff and draft picks. Expectations are low for Dan Campbell’s team in his first year as a head coach.

Bills at Lions odds, spread and lines

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:50 a.m. ET.

Money line: Bills +100 (bet $100 to win $100) | Lions -125 (bet $125 to win $100)
Against the spread/ATS: Bills +1.5 (-105) | Lions -1.5 (-115)
Total: 36.5 (O: -110 | U: -110)

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Bills at Lions odds, lines, predictions and picks

Prediction

Bills 17, Lions 14

Money line

The Bills aren’t going to play their primary starters, but it won’t just be backups on the field. Players who are battling for starting jobs could see some action, which will help Buffalo in this game.

Detroit is expected to be one of the worst teams in football and with this being Campbell’s first game, I’m not expecting a whole lot out of Goff and the Lions offense. Bet the BILLS (+100) at even money.

Against the spread

It’s hard to predict preseason games, especially the first preseason game of the year when most starters don’t play or stay on the field only for a brief time. The Bills have the better roster from top to bottom, with Detroit lacking talent even in its starting lineup.

Bet the BILLS +1.5 (-105) to cover the spread and even win outright on the road.

Over/Under

Preseason openers are typically low-scoring, with two of the first three games this year totaling 35 or fewer points. The Lions don’t have much in the way of an offense, and Buffalo’s backup quarterbacks leave a lot to be desired, led by QB Mitchell Trubisky.

Don’t expect many points to be put up on the board, especially with Buffalo’s defense looking strong on paper – even in the second unit. Bet the UNDER 36.5 (-110).

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Buffalo Bills at Detroit Lions odds and lines: QB Jared Goff makes unofficial Lions debut

Looking at Friday’s Buffalo Bills at Detroit Lions NFL preseason odds and lines.

The Buffalo Bills made it within one game of the Super Bowl last season and seek to unseat the two-time defending AFC champion Kansas City Chiefs. Their quest begins this week in their preseason opener against the Detroit Lions.

Meanwhile, the Lions will give QB Jared Goff his unofficial debut with the team. Goff was acquired from the Los Angeles Rams in the trade that sent QB Matthew Stafford to California.

This preseason opener for both teams will kick off Friday night at 7 p.m. ET at Ford Field in Detroit. Below, we look at the Bills at Lions odds and lines.

Bills at Lions: Odds, spread and line

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 1:20 p.m. ET.

Money line: Bills -133 (bet $133 to win $100) | Lions +110 (bet $100 to win $110)
Against the spread/ATS: Bills -2.5, -105 (bet $105 to win $100) | Lions +2.5, -115 (bet $115 to win $100)
Total: 36.5, Over -125 (bet $125 to win $100) | Under +100 (bet $100 to win $100)

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2020 Betting stats:

ATS: Bills 12-7 | Lions 7-9
O/U: Bills 12-6-1 | Lions 10-6

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The Lions, at +110 odds, have an implied 46.72% chance of winning, or 11/10 fractional odds. If Detroit wins outright or loses by less than a field goal, a Lions +2.5 (-105) ATS bet wins.

The Bills (-130) have an implied 57.08% chance of beating the Lions, or 100/133 fractional odds. Buffalo must win by at least three points for a Bills -2.5 (-115) ATS ticket to cash.

There would need to be at least 37 points scored Friday for an OVER 36.5 (-125) ticket to cash, while a combined point total of 36 or fewer points is a win for the Under (+100).

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