Bills Titans odds picks prediction spread over/under betting line

On Monday Night Football, the Buffalo Bills (4-1) visit the Tennessee Titans (3-2). The game is set to kick off at 8:15 p.m. ET and will be held at Nissan Stadium. Below, we look at the Bills vs. Titans prop bet odds and lines, and make our best NFL picks, predictions and bets.

The Bills are coming in this game having beat the Kansas City Chiefs by 18 last week.

They’ve won their last four games by a combined 115 points, shutting out the Texans and Dolphins. This team has just taken their game to a new level behind MVP-favorite Josh Allen.

As for the Titans, they’ll be returning Julio Jones and A.J. Brown. Along with Derrick Henry, who is on pace to break the single-season rushing record, Tennessee has an elite offense as well.

This should be a thrilling game. That said, let’s dive into the player props you should consider taking.

Bills at Titans prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:30 a.m. ET.

Bills QB Josh Allen OVER 292.5 passing yards (-114)

Allen has been on fire over the last few weeks. Having been able to take off the gas against Houston with the Bills annihilating the Texans, Allen has surpassed 293 yards in two of his last three games.

He had 315 yards on 15 completions in a rain-heavy game against the Chiefs. With the Titans ranking 21st in opponents’ passing yards per game, Allen should be able to expose a weak Tennessee pass defense.

Given his strong recent play and a poor Tennessee defense, I’d play the Over for the MVP hopeful.

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Titans RB Derrick Henry OVER 13.5 receiving yards (-114)

Derrick Henry was left out of the passing game last week, not seeing a single target.

So far this season, that has been a rarity. Henry has surpassed 13 yards in all four of the team’s other games this season. He’s 4-for-5 on this prop this season.

With the clear strength of this team being his ability to run, that is the focal point for defenses. Buffalo has given up more than 20 receiving yards to running backs in its last four games.

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Bills WR Emmanuel Sanders Anytime TD scorer (+155)

Allen has been electric, and Emmanuel Sanders has become a key end zone threat for him. Sanders has had four touchdowns in the Bills’ last three games.

With Allen surging, Sanders, an offseason addition for Buffalo, has continued as a top weapon. He has seen at least five targets in all five of Buffalo’s games this season.

This should be a high-scoring game with Buffalo having put up at least 35 in four straight games. Expect Allen to score often, and with Sanders becoming a red-zone favorite, he should get a couple of chances to score.

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NFL pointspread favorites enjoyed their first winning week of the season in Week 5, but were unfazed here in Underdog Corner, hitting on two of our three selections to notch our fourth winning week of the season.

With the Cincinnati Bengals and Buffalo Bills cashing, it ups our 2021 record to a nice and profitable 11-4 (.733).

Let’s see if we can keep the train rolling with our NFL underdog ATS picks and predictions of Week 6.

Also see: All Week 6 odds and lines

NFL underdog predictions: Week 6

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 6:41 p.m. ET.

Jacksonville Jaguars +3.5 (-117) vs. Miami Dolphins

The NFL is serving up another London dud as the winless Jaguars take on the 1-4 Dolphins, whose only victory was a 17-16 opening-week escape at the New England Patriots.

Moreover, each side’s offense and defense rank as a bottom-five NFL unit in terms of scoring and points allowed per game.

Dolphins QB Tua Tagovailoa is hoping to play after a three-week IR stint with a rib injury, and that should provide a boost for a Miami offense which ranks 30th in passing (191.4 yards per game).

But with rookie QB Trevor Lawrence getting his NFL legs under him and the Jags owning a significant advantage in the run game with stud second-year RB James Robinson (fourth in the league with 387 yards while averaging 5.8 yards per attempt), there’s no reason why Miami should be favored by anything more than a point or two.

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Detroit Lions +3.5 (-110) vs. Cincinnati Bengals

Yep, we’re on each of the league’s winless teams this week.

Head coach Dan Campbell’s 0-5 Lions have been particularly feisty with a 3-2 record against the spread and losing two of their last three on 54-yard-plus field goals on the game’s final play.

Led by the QB Joe Burrow– WR Ja’Marr Chase LSU connection that’s already clicked for five TDs, the Bengals are 3-2. But they are also 2-3 ATS, now a road favorite for only the third time since 2018 and are in a prime look-past-the-winless-opponent spot with a game against the division-leading Baltimore Ravens looming next week.

Take the scrappy Lions and the field goal-plus.

WIN YOUR FANTASY FOOTBALL LEAGUE!

For 25 years, TheHuddle.com has been helping fantasy players just like you win. This year, it’s your turn! Custom player rankings, tools and more to give you the edge over your competition.

Use code SBW21 to take 20% OFF a new subscription. Join now!

Tennessee Titans +5.5 (-110) vs. Buffalo Bills

Speaking of red-flag letdown spots, the 4-1 Bills are playing in their second straight primetime road game after notching a massive revenge 38-20 win at the host Kansas City Chiefs Sunday night.

The Tennessee defense, ranked 24th with 26.0 points allowed per game, is a clear concern facing Bills QB Josh Allen and the league’s highest-scoring offense (34.4 points). But if the 3-2 Titans can avoid turnovers (Buffalo has an NFL-most 15 takeaways) and get league rushing leader RB Derrick Henry (640 yards, 7 TDs) and the play-action game going with capable QB Ryan Tannehill, the hosts should be able to keep this Monday night matchup close.

If you hold off until closer to kickoff, you might even be able to catch more points with the Titans as the line has already gone up two full points after opening at Bills -3.5.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow @kenpomp on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

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