Buffalo Bills at LA Rams odds, picks and predictions

Analyzing Sunday’s Buffalo Bills at LA Rams odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (10-2) are visiting the LA Rams (6-6) Sunday for a marquee matchup in Week 14. Kickoff from SoFi Stadium is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Rams odds, and make our expert NFL picks and predictions.

The Bills have won 7 straight games, scoring at least 30 points in each of their last 6 games. At 10-2, they’re just 1 game behind the Kansas City Chiefs for the No. 1 seed in the AFC, and they hold the tiebreaker after winning their head-to-head matchup this season. Most recently, they crushed the San Francisco 49ers, 35-10, on Sunday Night Football in Week 13.

The Rams come into this one with a 6-6 record after winning just 2 of their last 4 games. They came back to beat the New Orleans Saints, 21-14, in Week 13, getting back to the .500 mark for the second time this season. They’ve yet to have a winning record at any point this year but they’ll have a chance to change that with a win over the Bills.

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Bills at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 8 p.m. ET.

  • Moneyline (ML): Bills -190 (bet $190 to win $100) | Rams +155 (bet $100 to win $155)
  • Against the spread (ATS): Bills -3.5 (-115) | Rams +3.5 (-105)
  • Over/Under (O/U): 49.5 (O: -110 | U: -110)

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Bills at Rams key injuries

Bills

  • WR Keon Coleman (wrist) questionable
  • TE Dalton Kincaid (knee) questionable

Rams

  • OL Alaric Jackson (foot) probable
  • OLB Jared Verse (ankle) probable

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Bills at Rams picks and predictions

Prediction

Bills 30, Rams 27

Moneyline

PASS on the moneyline. The Bills are on the road against a motivated Rams team, so they could be ripe for a letdown, especially after winning 7 games in a row. They’re just not worth betting on their own at -190.

Against the spread

The Bills have covered the spread in 3 straight games and 6 of their last 7, but the Rams are 4-2 ATS in their last 6 and have shown signs of improvement now that they’re fully healthy. The offensive line is at full strength, their receiving corps is healthy and the defense should be able to generate interior pressure against the Bills’ guards.

With the spread sitting at a key number of 3.5, BET RAMS +3.5 (-105) to cover and keep this one close.

Over/Under

The Bills have scored at least 30 points in 6 straight games and that’s not likely to change against a Rams defense that’s given up 582 rushing yards in their last 3 games, an average of 194 per game. The Rams, meanwhile, scored 21 points in the second half of Sunday’s win over the Saints and could find success running it against Buffalo’s defense, which is allowing 4.9 yards per carry.

BET OVER 49.5 (-110).

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Buffalo Bills at Los Angeles Rams odds, picks and predictions

Analyzing Thursday’s Buffalo Bills at Los Angeles Rams Week 1 odds and lines, with expert NFL picks, predictions and best bets.

What better way to kick off the 2022 NFL season than with the defending champions hosting the Super Bowl favorites? That’s what we have Thursday night with the Los Angeles Rams taking on the Buffalo Bills at SoFi Stadium. Kickoff is set for 8:20 p.m. ET (NBC) from Inglewood. Below, we analyze Tipico Sportsbook‘s lines around the Bills vs. Rams odds, and make our expert NFL picks and predictions.

The Rams are the reigning Super Bowl champions after beating the Cincinnati Bengals in February in their home stadium. They’re among the betting favorites in the NFC, close behind the Tampa Bay Buccaneers and Green Bay Packers. Though they suffered some key losses in the offseason, including OLB Von Miller and RG Austin Corbett, the Rams are built to contend for another championship this season.

The Bills are the betting favorites to win it all this season after coming close to reaching the big game last year. Led by QB Josh Allen, the Bills added Miller in free agency and return star players such as CB Tre’Davious White and WR Stefon Diggs. They boasted the No. 1 defense in football last season, but that very defense was unable to stop the Chiefs in the AFC divisional round last postseason.

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Bills at Rams odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 7:11  p.m. ET.

  • Money line (ML): Bills -135 (bet $135 to win $100) | Rams +115 (bet $100 to win $115)
  • Against the spread (ATS): Bills -2.5 (-115) | Rams +2.5 (-105)
  • Over/Under (O/U): 51.5 (O: -112 | U: -108)

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Bills at Rams key injuries

Bills

  • OL Tommy Doyle (foot) questionable
  • TE Quintin Morris (hamstring) questionable

Rams

  • WR Van Jefferson (knee) questionable

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Bills at Rams picks and predictions

Prediction

Rams 30, Bills 24

Money line

It’s rare for the defending Super Bowl champions to be underdogs in the season opener, but that’s more a testament to the Bills’ talent than it is an indictment of the Rams. Los Angeles is just as talented as it was last season, even with the losses it suffered in free agency.

The Rams are 5-0 in Week 1 under Sean McVay and I don’t think this will be the first time he loses a season opener. I like the RAMS (+115) to win outright, especially being at home and with the line sitting at plus-money.

Against the spread

As good as the Rams have been in season openers under McVay, they’re also perfect against the spread. They’re 5-0 ATS in Week 1 the last 5 years, and now they’re getting 2.5 points at home against the Bills.

The better value is still in taking the Rams to win outright at +115, but even taking them +2.5 at -105 is worth a bet. Take the RAMS +2.5 (-105) to cover the spread, though I’d make it a smaller wager as insurance for your ML bet.

Over/Under

The Rams and Bills are both expected to be among the most explosive offenses in the NFL, and that will be on display Thursday night. In limited preseason action, the Bills offense looked sharp and as good as expected.

This will be the 1st game action for the Rams starters, but I don’t think it’ll take them long to get going. They dropped 34 in Stafford’s debut last season against the Chicago Bears. Give me the OVER 51.5 (-112).

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