First look: Buffalo Bills at Chicago Bears odds and lines

Looking at Saturday’s Bills at Bears Week 16 NFL odds, lines and trends. Here’s what you need to know.

The Buffalo Bills (11-3) and Chicago Bears (3-11) meet Saturday for a Week 16 clash at Soldier Field. Kickoff is slated for 1 p.m. ET (CBS). Below, we look at Bills vs. Bears odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Buffalo played Saturday, failing to cover a 7-point spread but defeating the Miami Dolphins 32-29. QB Josh Allen threw for 304 yards and 4 TDs and ran the ball 10 times for 77 yards. The win was the Bills’ 5th in a row and 4 have been of the 1-score variety.

The Bears lost to the Philadelphia Eagles 25-20 Sunday. Chicago was a +8.5 underdog and got an against-the-spread (ATS) win to snap a 4-game losing streak in that regard. But overall, the struggling Bears have lost 7 in a row straight-up.

Also seeAll Week 16 odds and lines

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Bills vs. Bears odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8:45 a.m. ET.

  • Moneyline: Bills -400 (bet $400 to win $100) | Bears +325 (bet $100 to win $325)
  • Against the spread (ATS): Bills -9.5 (-110) | Bears +9.5 (-110)
  • Over/Under (O/U): 41.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Bills 11-3 | Bears 3-11
  • ATS: Bills 6-7-1 | Bears 5-8-1
  • O/U: Bills 4-10 | Bears 9-5

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Bills at Bears head-to-head

Buffalo and Chicago are meeting for the 14th time, but for the 1st time since 2018. The Bears have won 3 of the last 4 meetings and are 8-5 vs. the Bills.

Against the number, though, the series is a 1-1-1 proposition since 2010, with each side claiming an ATS win alongside a push.

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