How have the Cardinals done against the 49ers?

The Cardinals are 12-4 against the 49ers over the last eight years. They’ll need some of that success in Week 11.

The Arizona Cardinals and San Francisco 49ers will both travel to Mexico City in what is a pivotal matchup for the NFC West.

If the Cardinals can win, they’ll be a game back from .500 and have a much more realistic shot of making the postseason as a wild card team. If the 49ers win, they’ll tie the Seahawks in wins and get closer to first place.

The 49ers lead the all-time series 32-29, so the Cardinals will not be able to take the lead in this season even if they pull off another sweep.

Last season, the Cardinals swept the 49ers, a rival they’ve had a great deal of success against. The team is 12-4 in their last 16 games played, so the recent matchups have very much gone in favor of the Cardinals.

With that in mind, how have the Cardinals done against the 49ers in recent memory? Analyzing trends is always key when looking at an upcoming matchup.

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Arizona Cardinals vs San Francisco 49ers Prediction, Game Preview

Arizona Cardinals vs San Francisco 49ers prediction, game preview, and fantasy player to watch.

Arizona Cardinals vs San Francisco 49ers prediction, game preview, and fantasy player to watch.


Arizona Cardinals vs San Francisco 49ers Broadcast

Date: Saturday, December 26
Game Time: 4:30 ET
Venue: State Farm Stadium, Glendale, AZ
Network: Amazon Prime Video

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Arizona Cardinals (8-6) vs San Francisco (5-9) Game Preview

For latest lines and to bet on the NFL, go to BetMGM


Why San Francisco Will Win

The Niners get to play the role of spoiler in a rare road game that’s not a road game – at least for the moment. They’ve been used to their temporary home in Glendale, and with no crowd, any sort of road advantage for the other side doesn’t matter.

The Cardinals pulled up out of their nosedive with tow straight wins, but the pass defense has bee hit hard for over 300 yards in two of the last three games. The Niners might not be winning, but they’re putting up a ton of yards through the air with close to 900 in the last three games, but …

Why Arizona Cardinals Will Win

San Francisco can’t stop turning the ball over.

All of the injury losses and all of the issues have stacked up in the ugly second half of the season. The defense is still tough, but the offense keeps putting that D in bad position after bad position with mistakes.

San Francisco has turned it over multiple times in each of the last eight games and in ten of the last 11. Arizona seems to find ways to overcome its turnovers, but it’s great when it’s the one forcing the errors going 5-1 when forcing multiple takeaways.

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Fantasy Football Player To Watch

TE George Kittle, San Francisco
Are you really going to trust Kittle in your biggest game of the season? Back from the foot injury that kept him out over the last several weeks. He needs to be a part of the San Francisco midrange passing game that’s generating yards, but not enough success. Kittle only has two touchdown catches and two 100-yard games, but he’ll be targeted at least seven times.

What’s Going To Happen

Arizona desperately needs this to stay alive in the playoff hunt. It’s clinging to the final spot, but San Francisco is just dangerous enough to screw things up with a tough defense and a passing attack that can get hot.

However, the Niners will turn it over just enough to let the Cardinals overcome their own mistakes to get a harder-fought win that they might like.

Arizona Cardinals vs San Francisco 49ers Prediction, Line

Arizona 30, San Francisco 24
Bet on Arizona Cardinals vs San Francisco 49ers with BetMGM
Arizona -5, o/u: 49.5
ATS Confidence out of 5: 3

Must See Rating: 3

5: Die Hard
1: Every other Christmas movie ever made

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