The Arizona Cardinals (4-12) wrap up the regular season on the road against the NFC West champion San Francisco 49ers (12-4) in Week 18. Kickoff is Sunday at 4:25 p.m. ET at Levi’s Stadium in Santa Clara (FOX). Below, we look at Cardinals vs. 49ers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Cardinals lost their 6th consecutive game Sunday, falling to the Atlanta Falcons 20-19 on a last-second 21-yard field goal. They covered the 7-point spread as underdogs with fourth-string QB David Blough starting.
The 49ers have won 9 straight games, recently needing overtime for a 37-34 victory at the Las Vegas Raiders in Week 17. However, they failed to cover as 10-point favorites, snapping a streak of 6 consecutive covers.
Also see: All Week 18 odds and lines
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Cardinals at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 12:08 a.m. ET.
- Moneyline (ML): Cardinals +650 (bet $100 to win $650) | 49ers -1000 (bet $1,000 to win $100)
- Against the spread (ATS): Cardinals +14 (-104) | 49ers -14 (-116)
- Over/Under (O/U): 40.5 (O: -110 | U: -110)
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2022 betting stats
- ML: Cardinals 4-12 | 49ers 12-4
- ATS: Cardinals 8-8 | 49ers 10-6
- O/U: Cardinals 8-8 | 49ers 8-8
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Cardinals vs. 49ers head-to-head
The 49ers won the first meeting in Week 11 in Mexico City 38-10 as 10-point favorites — the Cardinals were the designated home team. The 49ers hold a slight 33-29 all-time advantage, but the Cardinals have won 2 of the last 3.
This will be 49ers QB Brock Purdy’s 1st career start against the Cardinals.
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