AC Milan vs. Napoli odds, picks and predictions

Analyzing Wednesday’s AC Milan vs. Napoli odds and lines, with Champions League expert picks, predictions and best bets.

AC Milan welcomes Napoli to San Siro Wednesday for the 1st leg of their UEFA Champions League quarterfinal. Kickoff is set for 3 p.m. ET. Below, we analyze BetMGM Sportsbook’s lines around the AC Milan vs. Napoli odds, and make our best Champions League bets, picks and predictions.

AC Milan finished 2nd in Group E, winning 3 games, losing 2 and drawing 1. AC Milan scored 12 goals and allowed 7. It qualified for the Round of 16, where it took down Tottenham by a combined 1-0. Milan sits 4th in Serie A, the top Italian League. F Rafael Leao leads the club with 20 goals in 22 starts.

Napoli won Group A, going 5-1 with 20 goals and 6 against. Napoli is 1st in Serie A and 13-1-1 on the road in league play. Nigerian F Victor Osimhen leads Napoli with 21 goals in 22 starts. Napoli took down Eintracht Frankfurt by a combined 5-0 in the Round of 16.

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AC Milan vs. Napoli odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:20 a.m. ET.

  • Moneyline: AC Milan +170 (bet $100 to win $170) | Napoli +170 (bet $100 to win $170) | Draw +210
  • Over/Under: 2.5 (O: +120 | U: -175)

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AC Milan vs. Napoli picks and predictions

Prediction

Napoli 2, AC Milan 1

Moneyline (ML)

LEAN NAPOLI (+170).

Napoli has been dynamic this season and has been even better on the road than at home. It has won its last 8 road games throughout all competitions, including its last 7 league road matches.

Given this is a matchup between two Serie A teams, they should be familiar with each other. Milan beat Napoli on the road 4-0 April 2, and that will likely be remembered by the road side. Napoli has won 11 of its last 13 games as well.

Milan has a weaker defense and has lost 2 of its last 6 and has only won 1 of its last 6. Milan lost to Napoli 2-1 at home earlier in the season (Sept. 18).

Expect a matchup similar to that 1st meeting. BET NAPOLI (+170).

Over/Under (O/U)

BET OVER 2.5 (+120).

Napoli has gone Over in 3 of its last 4 games and went Over in 1 of its 2 Round of 16 games, having more than 2.5 expected goals in both matchups. Napoli has scored at least 2 goals in 14 of its last 16 games.

Milan put 4 on Napoli just over a week ago and should have success against a familiar attack. Milan averages 1.66 goals per game and allows 1.24 per game.

Both teams have dynamic offenses, and with a familiarity between them, they should play this game at a similar pace as their league matches, both of which went Over this total.

BET OVER 2.5 (+120).

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