The Tennessee Titans (9-5) host the San Francisco 49ers (8-6) Thursday for their Week 16 showdown at Nissan Stadium with the kickoff scheduled for 8:20 p.m. ET. Below, we look at the 49ers vs. Titans odds and lines; check back for our NFL picks and predictions.
San Francisco bullied the Atlanta Falcons in a 31-13 victory at home in Week 15, easily covering as a 9.5-point favorite. The 49ers gained 10 more first downs, 122 more total yards and held the Falcons to 1-for-5 on red-zone trips.
San Francisco’s ground game accumulated 162 rushing yards on 32 attempts with RB Jeff Wilson Jr.‘s 110 yards leading the group.
Tennessee gave up 16 unanswered, second-half points in its 19-13 loss to the Pittsburgh Steelers in Week 15. The Titans had nearly double the total yards (318-168) and double the time of possession (39:08-20:52) but sunk due to their minus-4 turnover differential.
Also see: All Week 16 odds and lines
49ers at Titans odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 10:55 a.m. ET.
- Money line: 49ers -180 (bet $180 to win $100) | Titans +145 (bet $100 to win $145)
- Against the spread (ATS): 49ers -3.5, -103 (bet $103 to win $100) | Titans +3.5, -117 (bet $117 to win $100)
- Over/Under (O/U): 44.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)
Also see: Betting 101
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2021 betting records:
- ML: 49ers 8-6 | Titans 9-5
- ATS: 49ers 7-7 | Titans 8-6
- O/U: 49ers 7-7 | Titans 7-7
49ers at Titans head-to-head
This will be the first meeting between these two teams since the Titans hired head coach Mike Vrabel in 2018. San Francisco beat Tennessee 25-23 at home in Niners head coach Kyle Shanahan’s first year on the job (2017).
Since 2018, the Titans are 7-5 ATS as home underdogs, 9-7 ATS vs. NFC teams, 12-9-1 ATS after a loss and 2-1 overall (2-1 ATS) on Thursdays.
In the Shanahan era, the 49ers are 8-7 ATS as road favorites, 12-8 ATS vs. NFC teams, 20-17 ATS following a win and 2-2 overall (2-2 ATS) on Thursdays.
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