The Los Angeles Chargers are 7.5-point underdogs to the San Francisco 49ers in Week 10 of the 2022 regular season. The over/under is 45.5 points, per Tipico Sportsbook.
That means oddsmakers are taking bets on whether the two teams will combine to score more than or fewer than 45.5 points.
My score prediction for the game is a 28-21 win for the 49ers, with a combined total of 49 points. So if I were putting money behind my prediction, I’d bet the over.
As for game picks, analysts favor Kyle Shanahan’s Niners in this primetime showdown.
| Expert | Pick |
| Nate Davis (USA Today) | 49ers |
| Jarrett Bell (USA Today) | 49ers |
| Mike Clay (ESPN) | 49ers |
| Matt Bowen (ESPN) | 49ers |
| Pete Prisco (CBS Sports) | 49ers |
| Bill Bender (Sporting News) | Chargers |
| Gregg Rosenthal (NFL Media) | 49ers |
| Bleacher Report | 49ers |
Sunday’s game will begin at 5:20 p.m. PT and will be televised on NBC.