First look: San Francisco 49ers at Green Bay Packers odds and lines

Looking at Sunday’s San Francisco 49ers at Green Bay Packers Week 12 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (5-5) meet the Green Bay Packers (7-3) in a Sunday contest at Lambeau Field. Kickoff is scheduled for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Packers odds, and make our expert NFL picks and predictions.

The 49ers will head to Wisconsin looking for their third straight road win, but on Sunday they fell 20-17 to the visiting Seattle Seahawks. The favored-by-6 49ers had a lead late, but Seahawks QB Geno Smith ran in a 12-yarder with 12 seconds left to cap a game-winning, 11-play, 80-yard drive.

The Packers ran their record since the beginning of October to 5-1 with a 20-19 win at the Chicago Bears Sunday. A QB Jordan Love touchdown at the 2:59 mark of the fourth quarter helped the Packers (-6) to the win. Green Bay blocked a would-be game-winning field goal as time expired.

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49ers at Packers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 7:23 a.m. ET.

  • Moneyline: 49ers +100 (bet $100 to win $100) | Packers -120 (bet $120 to win $100)
  • Against the spread (ATS): 49ers +1.5 (-110) | Packers -1.5 (-110)
  • Over/Under (O/U): 47.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: 49ers 5-5 | Packers 7-3
  • ATS: 49ers 4-6 | Packers 4-6
  • O/U: 49ers 5-5 | Packers 4-5-1

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49ers vs. Packers head-to-head

The last 2 San Francisco-Green Bay games have been playoff tilts, and the 49ers won both. Overall, their series includes 10 postseason meetings, and the Packers lead the series 38-34-1.

Since 2019, the 49ers are 4-2 straight up and 3-3 ATS. The last 3 meetings have been 1-score football games.

Since 2015, each side has 4 SU wins and 4 ATS wins. And the O/U has also seen a 4-4 split.

The last 10 series games at Lambeau Field have netted 7 Green Bay wins and 3 for San Francisco. Over that span, ATS betting has produced a 4-4-2 split. The Over has a 6-4 edge across the last 10 games at Green Bay.

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