The San Francisco 49ers (3-2) visit the Atlanta Falcons (2-3) in an inter-divisional NFC matchup Sunday. Kickoff from Mercedes-Benz Stadium is slated for 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Falcons odds, and make our expert NFL picks and predictions.
The 49ers are rolling heading into this game, winning their last 2 games and looking like one of the strongest defenses in the league.
Since QB Jimmy Garoppolo has been starting – due to QB Trey Lance’s season-ending injury in Week 2 – the 49ers have gone 3-1. The loss in that stretch was an 11-10 setback in a defensive Sunday Night Football matchup at Denver in Week 3.
Garoppolo is completing 60.7% of his passes (65 of 107 attempts) for 857 yards and 5 TDs to only 1 interception.
Atlanta is looking to bounce back after suffering a tough 21-15 defeat vs. divisional opponent Tampa Bay last Sunday.
The Falcons will be looking to string together some wins vs. strong opponents. All 3 of their losses have been in one-score games – 27-26 at home to the Saints in the season opener, 31-27 to the Rams in Week 2 and the recent 6-point loss to the Bucs.
QB Marcus Mariota has completed 57.7% of his passes (71 of 123 attempts) for 926 yards and 4 TDs to 4 interceptions.
Also see: All Week 6 odds and lines
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
49ers at Falcons odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:38 p.m. ET.
- Moneyline (ML): 49ers -220 (bet $220 to win $100) | Falcons +180 (bet $100 to win $180)
- Against the spread (ATS): 49ers -4.5 (-110) | Falcons +4.5 (-110)
- Over/Under (O/U): 45.5 (O: -105 | U: -115)
Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!
49ers at Falcons key injuries
49ers
- DL Arik Armstead (foot, ankle) out
- OL Aaron Banks (knee) questionable
- DL Nick Bosa (groin) questionable
- DL Javon Kinlaw (knee) out
- CB Emmanuel Moseley (knee) out
- DB Jimmie Ward (hand) out
- OL Trent Williams (ankle) out
Falcons
- LB Adetokunbo Ogundeji (shoulder) questionable
- RB Cordarrelle Patterson (knee) IR
- TE Kyle Pitts (hamstring) questionable
- LB Mykal Walker (groin) out
- OG Elijah Wilkinson (knee) questionable
Play our free daily Pick’em Challenge and win! Play now!
49ers at Falcons picks and predictions
Prediction
49ers 21, Falcons 10
Moneyline
AVOID
San Francisco (-220) is too heavy of a favorite for me to feel comfortable advising anyone to make this bet. The risk isn’t worth the reward and many of us understand that blowouts are very rare in the NFL. While I do believe the 49ers will win this game, I wouldn’t advise betting the moneyline here.
Against the spread
BET 49ERS -4.5 (-110).
The 49ers are simply better than the Falcons, which is why I believe this is your BEST BET.
The 49ers have the best run defense in the league, allowing 249.2 rushing yards per game. The Falcons are missing their best running back and one of their key linemen and they will have virtually no running game.
The Atlanta passing game is not terrible, but whether or not Pitts plays, will be key. With the 49ers only having one major offensive injury, they should be able to cover the spread in this game.
Over/Under
LEAN UNDER 45.5 (-115). I expect this to be a low-scoring game, which is why I would say this bet is your second best.
When fully healthy, the Falcons have proven that they can put up 20+ points fairly consistently, but that won’t be the case come Sunday. Not only are they not healthy, but they’re also playing against a strong defense for the 2nd week in a row.
Playing at home should help the Falcons, but it won’t be enough for them to score a lot of points. The 49ers have a strong offense, but it isn’t spectacular, which is why UNDER 45.5 (-115) should be a fairly safe bet.
More NFL Week 6 odds, picks and predictions
- Parlay: Let’s make some money
- Best picks: Underdogs | Player props | Survivor
Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.
Follow @payton_shanks on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]