First look: San Francisco 49ers at Atlanta Falcons odds and lines

Looking at Sunday’s San Francisco 49ers at Atlanta Falcons Week 6 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (3-2) are on the road in Week 6 to face the Atlanta Falcons (2-3). Kickoff is Sunday at 1 p.m. ET at Mercedes Benz Stadium (FOX). Below, we look at 49ers vs. Falcons odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The 49ers improved to 3-2 in Week 5 with a 37-15 win over the Carolina Panthers. QB Jimmy Garoppolo passed for 254 yards and 2 touchdowns and RB Jeff Wilson had 120 rushing yards and a touchdown on 17 carries. The 49ers are in first place in the NFC West.

The Falcons managed only 261 yards of total offense against the Tampa Bay Buccaneers. They fell behind 21-0 and rallied for 15 fourth-quarter points, but the Bucs were able run out the clock after the Falcons scored for the last time.

Also seeAll Week 6 odds and lines

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49ers at Falcons odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:40 a.m. ET.

  • Moneyline (ML): 49ers -250 (bet $250 to win $100) | Falcons +205 (bet $100 to win $205)
  • Against the spread (ATS): 49ers -5.5 (-115) | Falcons +5.5 (-105)
  • Over/Under (O/U): 42.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: 49ers 3-2 | Falcons 2-3
  • ATS: 49ers 3-2 | Falcons 5-0
  • O/U: 49ers 1-4 | Falcons 3-2

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49ers vs. Falcons head-to-head

Because they were division rivals in the NFC West before realignment in 2002, the 49ers and Falcons used to play each other twice a season. Including 2 playoff matchups, they have played 81 times dating back to 1966. The 49ers lead the all-time series 48-32-1.

They played last season with the Niners picking up a 31-13 home victory.

Including a playoff game after the 2012 season, the 49ers have won 4 of the last 5 meetings between the teams.

Garoppolo is 1-1 in 2 career starts against the Falcons, while Falcons QB Marcus Mariota is 1-0 in his 1 career start against the 49ers.

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