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The San Francisco 49ers (6-10) will face the Arizona Cardinals (7-9) on the road on Sunday to close out the season. Kickoff from State Farm Stadium is at 4:25 p.m. ET (FOX). Below, we look at 49ers vs. Cardinals odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
After being 6-4 at their bye week and in first place in the NFC West, the Cardinals have lost 5 of 6 games and been eliminated from division contention. They are coming off a 13-9 road loss to the LA Rams on Saturday, covering the 6.5-point spread as underdogs.
The 49ers lost 40-34 to the Detroit Lions at home on Monday night, unable to cover the 3.5-point spread as underdogs. They have lost 3 in a row and 6 of 7 games and clinched last place in the NFC West.
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49ers at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Tuesday at 9:18 a.m. ET.
- Moneyline (ML): 49ers +125 (bet $100 to win $125) | Cardinals -150 (bet $150 to win $100)
- Against the spread (ATS): 49ers +3 (-110) | Cardinals -3 (-110)
- Over/Under (O/U): 44 (O: -110 | U: -110)
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2024 betting stats
- ML: 49ers 6-10 | Cardinals 7-9
- ATS: 49ers 5-11 | Cardinals 10-6
- O/U: 49ers 9-6-1 | Cardinals 7-8-1
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49ers vs. Cardinals head-to-head
The Cardinals beat the 49ers in Week 5 in Santa Clara 25-24 on a last-minute field goal. They were 7.5-point underdogs.
The 49ers had won the previous 4 meetings and lead the all-time series 36-30 that dates back to 1951.
Cardinals QB Kyler Murray is 3-4 in 7 career starts vs. the Niners. 49ers QB Brock Purdy is 4-1 vs. the Cardinals, suffering his first loss to them this season in Week 5.
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