The San Francisco 49ers (2-2), losers of two in a row, are on the road in Week 5 to take on the undefeated Arizona Cardinals (4-0) in an NFC West divisional matchup. Their game Sunday kicks off at 4:25 p.m. ET at State Farm Stadium in Arizona. Below, we look at the 49ers vs. Cardinals odds and lines; check back for our NFL picks and predictions.
The 49ers lost their second straight game in Week 4, as they fell 28-21 at home to the Seattle Seahawks. They allowed QB Russell Wilson to throw a pair of touchdown passes and run for another. The Seahawks had only 234 total yards of offense but scored four touchdowns in four trips to the red zone.
The 49ers had two turnovers and lost QB Jimmy Garoppolo to a calf injury that will keep him out for at least a couple of weeks. Rookie QB Trey Lance threw two touchdown passes in the loss in relief of Garoppolo.
The Cardinals routed the previously undefeated Los Angeles Rams 37-20 on the road. QB Kyler Murray passed for 268 yards and 2 touchdowns and RB Chase Edmonds rushed for 120 yards on just 12 attempts.
Also see: All Week 5 odds and lines
49ers at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 3:20 p.m. ET.
- Money line: 49ers +190 (bet $100 to win $190) | Cardinals -240 (bet $240 to win $100)
- Against the spread (ATS): 49ers +5.5, -108 (bet $108 to win $100) | Cardinals -5.5, -112 (bet $112 to win $100)
- Over/Under (O/U): 50.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: 49ers 2-2 | Cardinals 4-0
- ATS: 49ers 1-3 | Cardinals 3-1
- O/U: 49s 2-2 | Cardinals 2-2
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49ers at Cardinals head-to-head
The Cardinals and 49ers split their season series a year ago, with each team winning on the road.
This will be the 60th time they meet. The 49ers lead the all-time series 32-27 and have won three of the last four matchups. Before that, the Cardinals had won eight straight in the series.
The 49ers are 20-18 against Arizona since realignment in 2002.
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