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The San Francisco 49ers (5-6) take on the Buffalo Bills (9-2) on Sunday Night Football in Week 13. Kickoff from Highmark Stadium is set for 8:20 p.m. ET (NBC). Below, we look at 49ers vs. Bills odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Niners suffered a setback in their attempt to get back into the playoff picture with a 38-10 loss at the Green Bay Packers last week. They failed to cover as 6-point dogs with QB Brock Purdy on the sidelines. He has a good chance to return this week. TE George Kittle was the lone bright spot on offense with 6 catches for 82 yards and a score.
The Bills are coming off their bye week after an emotional 30-21 victory over the Kansas City Chiefs in Week 11. QB Josh Allen made his claim in the NFL MVP race by going 27-for-40 for 262 yards, 1 TD and 1 INT while rushing 12 times for 55 yards and the eventual game-winning TD. RB James Cook made the most of his 9 rushes for 20 yards by scoring 2 TDs.
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49ers at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 1:56 p.m. ET.
- Moneyline (ML): 49ers +240 (bet $100 to win $240) | Bills -300 (bet $300 to win $100)
- Against the spread (ATS): 49ers +7 (-110) | Bills -7 (-110)
- Over/Under (O/U): 46 (O: -110 | U: -110)
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2024 betting stats
- ML: 49ers 5-6 | Bills 9-2
- ATS: 49ers 4-7 | Bills 7-4
- O/U: 49ers 6-5 | Bills 7-4
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49ers at Bills head-to-head
The Bills lead the all-time series 7-6, winning the last matchup in 2020 as they covered as 2.5-point favorites with a 34-24 victory in San Francisco. Allen was amazing, going 32-for-40 for 375 yards, 4 TDs and 0 INTs. The team has split the last 4 meetings since 2008 with a 2-2 ATS record as well. The Over cashed 3 of the 4 times.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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