St. Louis Cardinals at Arizona Diamondbacks odds, picks and predictions

Analyzing Wednesday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with expert MLB picks, predictions and best bets.

The St. Louis Cardinals (45-57) and the Arizona Diamondbacks (55-47) e wrap up a 3-game series Wednesday at Chase Field in Phoenix. First pitch is scheduled for 3:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Cardinals vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 3-2 after Tuesday’s 3-1 victory

The Cardinals lost for the 4th time in the last 5 games, splashing a bit of cold water on the team’s momentum after a 6-game winning streak from July 15-20. St. Louis managed just a single run Tuesday, the lowest offensive output for the Cards since getting blanked 14-0 on June 29 against the Houston Astros.

The Diamondbacks snapped a 5-game losing streak with Tuesday’s 3-1 win  behind RHP Merrill Kelly. The single run allowed by Arizona pitching was the lowest conceded since July 1 on the road against the Los Angeles Angels.

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Cardinals at Diamondbacks projected starters

RHP Jack Flaherty vs. RHP Zac Gallen

Flaherty (7-6, 4.39 ERA) makes his 20th start. He has a 1.53 WHIP, 4.5 BB/9 and 8.8 K/9 in 104 2/3 innings.

  • Last start: Loss, 6 IP, 4 ER, 8 H (2 HR), 1 BB, 6 K in a 4-3 road loss vs. the Chicago Cubs Friday
  • 2023 road splits: 3-3, 3.55 ERA (63 1/3 IP, 25 ER – 6 HR), .289 opponent batting average (OBA) in 11 starts
  • 2023 vs. Arizona: Loss, 6 IP, 4 ER, 4 H (1 HR), 3 BB, 4 K in a 6-3 home loss April 17

Gallen (11-4, 3.18 ERA) makes his 22nd start. He has a 1.06 WHIP, 1.8 BB/9 and 9.3 K/9 in 130 1/3 innings.

  • Last start: No-decision, 7 IP, 3 ER, 5 H, 0 BB, 5 K in a 7-5 road loss vs. the Atlanta Braves last Thursday
  • 2023 home splits: 9-0, 1.48 ERA (67 IP, 11 ER – 3 HR), .198 OBA in 10 starts

Cardinals at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:02 a.m. ET.

  • Moneyline (ML): Cardinals +125 (bet $100 to win $125) | Diamondbacks -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-155) | Diamondbacks -1.5 (+125)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

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Cardinals at Diamondbacks picks and predictions

Prediction

Diamondbacks 4, Cardinals 2

Moneyline

The DIAMONDBACKS (-155) are a slam-dunk play in the series finale behind the All-Star starter Gallen. In fact, it’s a bit surprising that this number is not a little higher.

Gallen is a dominant 9-0 with a minuscule 1.48 ERA in 10 home outings, and 9 of his 10 home outings have resulted in quality starts, too. The Cardinals (+125) will be on the short end in this getaway day game.

Run line/Against the spread

The DIAMONDBACKS -1.5 (+125) are a little more risky of a play on the run line, as they’re still just 1-5 in the last 6 games overall.

Arizona is also 1-5 in the last 6 games on the run line at home, losing 4 of the outings outright. Still, it covered Gallen’s only start during that stretch, and the Snakes have covered 3 straight games at home as a favorite with the All-Star on the mound.

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Over/Under

UNDER 8.5 (+100) is worth a look with Gallen on the bump. He has allowed 3 or fewer runs in 3 straight starts, and 5 of the previous 7 outings, too.

The Over has cashed in 4 of the last 6 starts for Flaherty, but the Under is 3-1 in his last 4 road outings.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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