The Sportsbook Wire team is here to help you with your Week 1 NFL picks. Our writers offer up their selections on the money line, spread and Over/Under for every game on the opening slate. Visit SportsbookWire.com for more NFL picks and predictions throughout the season.
The Dallas Cowboys got things started Thursday night by covering an 8.5-point spread in a 31-29 loss to the Tampa Bay Buccaneers. The game sailed well Over the projected total of 51.5 points in a stellar offensive display by both teams.
Also see: 2021 NFL team win totals
Odds by Tipico Sportsbook.
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