The San Francisco 49ers (2-1) and Seattle Seahawks (1-2) meet in Week 4 for an NFC West showdown. Kickoff is at 4:05 p.m. ET at Levi’s Stadium. Below, we look at the Seahawks vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.
The Seahawks lost back-to-back games after a season-opening win over the Indianapolis Colts. The issue has been defense, as Seattle allowed 33 points to the Tennessee Titans and 30 to the Minnesota Vikings. QB Russell Wilson has thrown 7 touchdown passes in three games without an interception.
The 49ers suffered their first loss of the season in Week 3, falling 30-28 to the Green Bay Packers on a last-second field goal after they had scored a go-ahead touchdown with under a minute left. The offense has been uneven, with 41 points in Week 1, only 17 in Week 2 and 28 in Week 3. The Niners have had defensive issues as well while allowing two of their three opponents to score 30 or more points.
Also see: Week 4 staff picks
Seahawks at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:40 p.m. ET.
- Money line: Seahawks +125 (bet $100 to win $125) | 49ers -155 (bet $155 to win $100)
- Against the spread (ATS): Seahawks +2.5 (+105) | 49ers -2.5 (-130)
- Over/Under (O/U): 51.5 (O: -115 | U: -105)
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Seahawks at 49ers key injuries
Seahawks
- WR Dee Eskridge (concussion) out
- RB Rashaad Penny (calf) out
- OT Brandon Shell (ankle) out
- LB Benson Mayowa (neck) questionable
49ers
- DT Javon Kinlaw (knee) questionable
- RB Elijah Mitchell (shoulder) doubtful
- DL Arik Armstead (adductor) questionable
- DL Kevin Givens (ankle) out
- RB JaMycal Hasty (ankle) out
- CB Emmanuel Moseley (knee) questionable
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Seahawks at 49ers odds, lines, predictions and picks
Prediction
49ers 34, Seahawks 28
Money line
The Seahawks handled a Colts offense that has struggled this season but have not stopped anyone else. The 49ers have been very good offensively in two of three games.
The Seahawks are the only team in the division with a negative point differential but they won 13 of the last 15 games between the two teams.
San Francisco lost their home opener and will not want to drop its first two at home. QB Jimmy Garoppolo was 7-3 at home over the previous two seasons.
Take the 49ERS (-155).
Against the spread
Both teams are 1-2 ATS this season.
The 49ers’ twos wins this year were each by 6 or more points. The Seahawks have not covered the spread in a loss, although this is the first game in which they’ve been underdogs.
This is really a toss-up game but expecting a 49ers win, 2.5 points is too few to think the Seahawks would lose but cover.
Take the 49ERS -2.5 (-130).
Over/Under
Both teams have one game where they kept their opponent under 20 points but their other two opponents scored at least 30.
Both offenses are explosive and both defenses have shown they can be scored on.
This will be a shootout. Take OVER 51.5 (-115).
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