Seattle Seahawks at San Francisco 49ers odds, picks and prediction

Previewing the Seattle Seahawks at San Francisco 49ers Week 17 betting odds and lines, with NFL betting picks, tips and predictions.

The Seattle Seahawks (11-4) have already locked up the NFC West and will simply be playing for playoff positioning in Week 17 when they visit the San Francisco 49ers (6-9). Sunday’s kickoff is set for 4:25 p.m. ET at the 49ers’ temporary home of State Farm Stadium in Glendale, Ariz. Below, we preview the Seahawks-49ers betting odds and lines and make our NFL picks and predictions.

Seahawks at 49ers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at noon ET.

  • Money line: Seahawks -295 (bet $295 to win $100) | 49ers +240 (bet $100 to win $240)
  • Against the spread/ATS: Seahawks -6.5 (-110) | 49ers +6.5 (-110)
  • Over/Under: 45.5 (O: -115 | U: -105)

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Seahawks at 49ers: Game notes

  • The 49ers are 1-3 in their last four games, and just 2-6 in their last eight.
  • The Seahawks won their first meeting with the 49ers 37-27 in Week 8. They covered a 1-point spread.
  • The Seahawks are 0-5 ATS in their last five road games.
  • Seattle is 8-2 in its last 10 games against San Francisco, going 6-4 ATS in those games.
  • The total has gone Under in each of the Seahawks’ last seven games

Seahawks at 49ers: Key injuries

Seahawks

  • RB DeeJay Dallas (ankle) out
  • CB Jayson Stanley (hamstring) out
  • Mike Iupati (neck) questionable
  • TE Greg Olsen (foot) questionable
  • RB Carlos Hyde (illness) questionable
  • Damarious Randall (foot) questionable
  • OT Brandon Shell (ankle) questionable

49ers

  • DL Kevin Givens (non-injury) out
  • DT Javon Kinlaw (knee) out
  • DB Tarvarious Moore (ankle) questionable
  • CB Emmanuel Moseley (hamstring) questionable
  • LB Mark Nzeocha (illness) questionable
  • WR Deebo Samuel (hamstring) out
  • CB Richard Sherman (calf) out
  • CB K’Waun Williams (shin) out
  • WR Brandon Aiyuk (ankle) out
  • LB Dre Greenlaw (calf) out

Seahawks at 49ers: Odds, betting lines, predictions and picks

Prediction

Seahawks 27, 49ers 20

Money line (?)

The 49ers have nothing to play for and could opt to take a guarded approach with some of their banged-up players. They’ve also shown very few signs of life in the last two months, only the Los Angeles Rams and Arizona Cardinals since November began.

The Seahawks have stepped up on defense and should be able to slow down San Francisco’s offense, rolling to a win by at least one score. Take the SEAHAWKS (-295).

Against the spread (?)

I like the Seahawks against the spread even more than the money line. They’ve had trouble covering lately, but the 49ers are a beatable team and Seattle’s defense has improved significantly since the last meeting between these teams.

Take the SEAHAWKS -6.5 (-110) to cover and head into the postseason riding some momentum.

Over/Under (?)

This one’s tricky. I don’t expect the 49ers to move the ball that consistently against the Seahawks, but Seattle is also going up against a strong 49ers defense. The Seahawks will find the end zone a few times and the 49ers will break a long play or two to spark the offense.

Take the OVER 45.5 (-115) in this game, even though the total has gone Under in each of the Seahawks’ last seven.

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