Seattle Mariners at Cleveland Guardians odds, picks and predictions

Analyzing Wednesday’s Seattle Mariners at Cleveland Guardians odds and lines, with MLB expert picks, predictions and best bets.

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The Seattle Mariners (44-31) and the Cleveland Guardians (44-26) play the middle contest of a 3-game series Wednesday at Progressive Field. First pitch is scheduled for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Mariners vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The Mariners fell behind 1-0 after 2 innings in the series opener Tuesday, but Seattle scored 7 unanswered runs from the 3rd inning through the 7th inning, and it held on for an 8-5 win as a slight underdog (+116) while the Over (8.5) cashed.

The Guardians suffered a 3rd consecutive loss Tuesday, tying a season high skid. Cleveland also dropped 3 in a row in a road sweep at the hands of the Chicago White Sox from May 9-11. Cleveland has been outscored 20-11 in the 3-game slid, cashing the Over in the past 2 outings.

Despite Tuesday’s Over result, the Mariners have hit the Under in 4 of the past 6 games. The Guardians have also hit the Under at a 4-2 clip in the past 6 games, while going 9-4 in the previous 13 contests.

Mariners at Guardians projected starters

RHP Bryan Woo vs. RHP Tanner Bibee

Woo (3-0, 1.07 ERA) makes his 7th start. He has a 0.53 WHIP, 0.5 BB/9 and 6.4 K/9 in 33 2/3 IP.

  • Last start: Win, 6 IP, 0 ER, 2 H, 0 BB, 6 K in 3-0 road win vs. Oakland Athletics last Thursday
  • 2024 road splits: 2-0, 1.50 ERA (18 IP, 3 ER), 0.50 WHIP, .141 opponents’ batting average (OBA), 1 HR, 0 BB, 14 K in 3 starts

Bibee (4-2, 3.94 ERA) makes his 15th start. He has a 1.17 WHIP, 2.4 BB/9 and 10.4 K/9 in 75 1/3 IP.

  • Last start: Loss, 5 1/3 IP, 4 ER, 4 H (2 HR), 1 BB, 11 K in 4-2 road loss vs. Cincinnati Reds last Wednesday
  • 2024 home splits: 2-1, 5.06 ERA (37 1/3 IP, 21 ER), 1.23 WHIP, .253 OBA, 5 HR, 9 BB, 41 K in 7 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Mariners at Guardians odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:14 a.m. ET.

  • Moneyline (ML): Mariners +110 (bet $100 to win $110) | Guardians -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Mariners +1.5 (-190) | Guardians -1.5 (+155)
  • Over/Under (O/U): 8 (O: -105 | U: -115)

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Mariners at Guardians picks and predictions

Prediction

Mariners 4, Guardians 2

Moneyline

The MARINERS (+110) are a strong play for the 2nd consecutive day as a road underdog.

Woo has torn it up for the M’s this season, turning in a minuscule 1.07 ERA through 6 starts. He has won both of his decisions in 3 road starts, too.

It won’t be easy, as the Guardians (-135) have a good one with Bibee on the hill. Runs should be at a premium in this battle on Wednesday night.

Run line/Against the spread

The Mariners +1.5 (-190) will you nearly 2 times your potential return, and that’s just too much risk for not enough reward if you require insurance and cannot back Seattle straight up.

Seattle cashed as the road ‘dog in the series opener Tuesday, and it’s a good bet straight up in the rematch.

If you like the M’s, just takes them straight up on the moneyline.

PASS.

Over/Under

UNDER 8 (-115) is a strong option after the Over connected on Tuesday.

Woo has allowed very little, and he should quiet the bats of the Guardians. Bibee has also been tremendous for Cleveland, and he’ll do a good job holding down the Mariners, too.

Runs should be at a premium in this potential pitcher’s duel.

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