San Francisco 49ers at Tennessee Titans odds, picks and predictions

[gambcom-standard rankid=”3011″ ]

The San Francisco 49ers visit the Tennessee Titans as both teams open the preseason. Kickoff from Nissan Stadium is set for 7 p.m. ET (NFL+). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Titans odds, and make our expert NFL picks and predictions.

San Francisco finished atop the NFC West last year with a 12-5 record en route to a Super Bowl appearance, where the Niners lost 25-22 in OT to the Kansas City Chiefs. The 49ers are in a standoff with WR Brandon Aiyuk, the team’s leading receiver last year, who is demanding a trade.

Tennessee ended last year with a 6-11 record, finishing in last place in the AFC South. The Titans drafted OT JC Latham with the 7th overall pick in the draft. The Titans lost RB Derrick Henry to the Baltimore Ravens in free agency.

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

49ers at Titans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:33 p.m. ET.

Moneyline (ML) 49ers +200 (bet $100 to win $200) | Titans -250 (bet $250 to win $100)
Against the spread (ATS): 49ers +5.5 (-110) | Titans -5.5 (-110)
Over/Under (O/U): 38.5 (O: -110 | U: -110)

[gambcom-standard rankid=”3012″ ]

49ers at Titans picks and predictions

Prediction

Titans 21, 49ers 10

Moneyline

PASS.

I like the Titans to pick up the win and cover as -250 favorites, but this heavy of a favorite is never worth the risk of betting on. Bet on the spread and/or total instead.

Against the spread

LEAN TITANS -5.5 (-110).

The Titans have expressed that most starters will play in a few drives in this game, which should give Tennessee enough of an edge to cover here when the backups take the reins.

This is a lean because neither team has great backups and because there are always unknowns in the preseason, especially with a team like Tennessee that has so many young guys.

Over/Under

BET UNDER 38.5 (-110).

Both squads are known for having very stout defensive units, and with both teams having backup QBs who have never done much in the NFL, the defenses should shine here.

With coach Mike Vrabelout the door for Tennessee, this defense may be slightly worse, but the pieces are still in place for me to have faith in this unit for this outing.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @payton_shanks on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]