The San Francisco 49ers (4-5) visit the New Orleans Saints (6-2) Sunday of Week 10 for a 4:25 p.m. ET kickoff. Below, we preview the 49ers-Saints betting odds and lines and make our NFL picks and predictions.
49ers at Saints: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 9:05 a.m. ET.
- Money line: 49ers +385 (bet $100 to win $385) | Saints -500 (bet $500 to win $100)
- Against the spread/ATS: 49ers +10 (-110) | Saints -10 (-110)
- Over/Under: 48.5 (O: -115 | U: -106)
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49ers at Saints: Game notes
- Hampered by injuries and WR Kendrick Bourne‘s positive COVID-19 test, the 49ers (+6) were shorthanded and no match for the Green Bay Packers in a 34-17 home loss in the Week 9 Thursday Night Football game. San Francisco has lost two in a row and is in last place in the NFC West.
- QB Jimmy Garoppolo, All-Pro TE George Kittle, RB Raheem Mostert and DE Nick Bosa were among the key 49ers who didn’t play Thursday and are not available for Week 10. WR Deebo Samuel and CB Richard Sherman hope to return.
- With Garoppolo out, Nick Mullens started at QB and threw for 291 yards with a TD and a pick. For the season, he has completed 68.4% of his passes for 1,143 yards with 5 TDs vs. 4 INTs.
- The Saints own a 5-game win streak after crushing the Tampa Bay Buccaneers 38-3 on the road as 3.5-point underdogs in the Week 9 Sunday Night Football game. New Orleans took over first place in the NFC South as QB Drew Brees threw for 222 yards and 4 TDs. The defense dominated the Bucs, keeping them off the scoreboard until 5:52 to go.
- Brees, who has completed 74% of his passes for 2,120 yards with 17 TDs against 3 picks this season has WR Michael Thomas back. The 3-time Pro Bowler returned last week (5 catches, 51 yards) after missing 5 games due to injuries and was benched for a game following an altercation at practice.
- The 49ers are 4-5 ATS, while the Saints are 3-5 ATS.
- San Francisco owns a 5-4 O/U record, averages 25.0 points per game and allows 23.0 PPG (ranking 10th in the NFL).
- Last week, New Orleans played its first Under game of the season after starting 7-0 vs. the O/U. The offense averages 30.5 PPG (4th), while the defense allows 25.0 PPG.
- The 49ers won at the Saints 48-46 last year (Dec. 8). PK Robbie Gould kicked a 30-yard field goal as time expired.
49ers at Saints: Key injuries
49ers
- RB Tevin Coleman (knee) questionable
- LB Demetrius Flannigan-Fowles (hamstring) out
- WR Deebo Samuel (hamstring) questionable
- DB Richard Sherman (calf) questionable
Saints
- OT Ryan Ramczyk (back) questionable
- WR Michael Thomas (ankle, hamstring) questionable
49ers at Saints: Odds, betting lines, predictions and picks
Prediction
Saints 33, 49ers 9
Money line (?)
AVOID. The Saints (-500) are going to win, but risking five times your return is not wise and not worth the payoff.
Against the spread (?)
NEW ORLEANS -10 (-110) is the STRONGEST PLAY – 1.5 times your usual wager. San Francisco is missing too many key pieces to make this competitive. It could get ugly real fast.
Over/Under (?)
The UNDER 48.5 (-106) is worth backing. Facing the undermanned 49ers, there’s a good chance the Saints defense doesn’t allow a touchdown in back-to-back games.
Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Also see:
- NFL Draft needs 1.0: A midseason check-in (Niners Wire)
- PFF: Saints pass rush best in NFL since Davenport debut (Saints Wire)
| Johnny’s 2020 NFL record / Strongest plays | 9-8-1 / 2-3-1 |
| 2019 NFL record / Strongest plays | 17-10-1 / 7-4 |
| 2020 overall record (all sports) | 138-104-3 |
| Strongest plays (all sports) | 68-39-1 |
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