San Francisco 49ers at Minnesota Vikings odds, picks and predictions

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The Minnesota Vikings (1-0) welcome the San Francisco 49ers (1-0) to U.S. Bank Stadium Sunday. Kickoff is set for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

The Vikings clobbered the New York Giants on the road in Week 1, winning 28-6 and covering as 1-point favorites. In its Week 1 battle, RB Aaron Jones led the way with 94 rushing yards and a TD on 14 carries. Former top-5 pick QB Sam Darnold ended with 208 yards, 2 TDs and an INT.

The 49ers beat up the visiting New York Jets 32-19 in Week 1 action, covering as 3.5-point favorites. They used a 13-0 second quarter to pull away in the Monday Night Football showdown. The 49ers were led by RB Jordan Mason, who rushed for 147 yards and a score on 28 carries — RB Christian McCaffrey was a late scratch.

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49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 9:05 p.m. ET.

Moneyline (ML): 49ers -225 (bet $225 to win $100) | Vikings +185 (bet $100 to win $185)
Against the spread (ATS): 49ers -4.5 (-110) | Vikings +4.5 (-110)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

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49ers at Vikings key injuries

Vikings

WR Jordan Addison (ankle) out
TE T.J. Hockenson (knee) out
QB J.J. McCarthy (knee) out
T Brian O’Neill (elbow) questionable
S Harrison Smith (hip) questionable

49ers

S Talanoa Hufanga (knee) doubtful
RB Christian McCaffrey (calf) out
WR Ricky Pearsall (chest/shoulder) out

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49ers at Vikings picks and predictions

Prediction

49ers 28, Vikings 23

Moneyline

PASS.

The 49ers (-225) are a well-coached, well-oiled machine and should be able to come out on top; however, they are too expensive to take on the moneyline.

Against the spread

BET 49ERS -4.5 (-110).

The Vikings throttled the Giants, who could be the worst team in the NFL. Darnold still had an interception and hasn’t proven he can consistently perform without turning the ball over. The 49ers have one of the best offensive lines in the NFL and should be able to find traction against a weak Vikings defensive line.

The 49ers went for over 220 rushing yards in Week 1 and are taking on a front ranked as the 30th-best unit in the NFL by PFF.com. Expect San Francisco to enforce its will in the trenches and ultimately cover. Both teams are entering 1-0 ATS.

Take 49ERS -4.5 (-110).

Over/Under

BET OVER 46.5 (-110).

There are playmakers on both sides of the ball that should do just that Sunday. The Vikings have a few superstars in Jones and WR Justin Jefferson, who both scored against the Giants. While Darnold isn’t great, he is serviceable and should be able to find his weapons.

The 49ers put up 32 points on one of the best defenses in the NFL and have the firepower to do that against a weaker Vikings side. Minnesota is 0-1 O/U due to the Giants putting up just 6 points. The 49ers are 1-0 O/U and were 12-8 O/U last season with a similar roster.

Take OVER 46.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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