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The San Francisco 49ers (5-1) face the Minnesota Vikings (2-4) at 8:15 p.m. ET Monday at U.S. Bank Stadium (ABC/ESPN). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.
After scoring 30 or more points in each of their first 5 games, the 49ers were shut down by the Browns 19-17 on Oct. 15 in the worst game of QB Brock Purdy‘s career. He completed just 12 of 27 passes for 125 yards with 1 touchdown and 1 interception. The 49ers are 4-2 against the spread (ATS).
The Vikings kept hope alive for their season with a 19-13 win over the Chicago Bears. The Vikings defense knocked Bears QB Justin Fields out of the game and needed a defensive touchdown from LB Jordan Hicks to lock down the win and improve Minnesota to 2-3-1 ATS.
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49ers at Vikings odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:13 p.m. ET.
- Moneyline (ML): 49ers -300 (bet $300 to win $100) | Vikings +240 (bet $100 to win $240)
- Against the spread (ATS): 49ers -7 (-105) | Vikings +7 (-115)
- Over/Under (O/U): 43 (O: -110 | U: -110)
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49ers at Vikings key injuries
49ers
- LB Dre Greenlaw (hamstring) questionable
- RB Christian McCaffrey (oblique) questionable
- WR Deebo Samuel (shoulder) out
- OT Trent Williams (ankle) doubtful
Vikings
- G Ezra Cleveland (foot) out
49ers at Vikings picks and predictions
Prediction
49ers 31, Vikings 17
Moneyline
PASS.
The 49ers should win this one with relative ease — even if their injured stars don’t play or are limited. But a 1:3 ratio for return on investment is too steep a price to pay.
Against the spread
TAKE 49ERS -7 (-105).
The 49ers are the best team in the NFC and can dominate on both sides of the ball. The Vikings and QB Kirk Cousins have struggled badly in prime-time games, and without Justin Jefferson, the team is without its most dynamic player.
The 49ers are capable of blowing the doors off the Vikings, even if McCaffrey is out or limited. The Vikings are among the worst teams in the league in terms of turnovers (13), and the 49ers lead the league in giveaway/takeaway ratio (plus-8). That’s a bad combination for the Vikings.
Over/Under
TAKE OVER 43 (-110).
The 49ers have scored 30 or more points in 5 of 6 games and have a good chance of doing that against Minnesota’s risk-taking, blitz-happy defense. Big plays will be available to the 49ers offense if the line can pick up Minnesota’s blitzes.
San Francisco has outscored its opponents 41-6 in the 1st quarter this season and 106-54 in the 1st half. If the Vikings get behind, they will become 1-dimensional and could end up passing 40 or more times. That should help give them enough points to do their part to get this score Over.
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