San Francisco 49ers at Los Angeles Rams odds, picks and predictions

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The San Francisco 49ers (1-0) and Los Angeles Rams (1-0) renew their rivalry Sunday in the first of two meetings this season. Kickoff from SoFi Stadium is set for 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.

The 49ers looked like one of the teams to beat this year in Week 1 as they crushed the Pittsburgh Steelers 30-7 as 1-point favorites. San Francisco was carried on offense by RB Christian McCaffrey who put up 152 rushing yards and 1 TD on 22 carries while the defense swarmed Steelers QB Kenny Pickett, holding Pittsburgh to just 15 first downs — 3 of which came from penalties.

The Rams stunned a lot of people with a lopsided win of their own in Week 1, beating the Seattle Seahawks 30-13 as 4-point underdogs. Los Angeles held Seattle to just 12 total yards in the 2nd half while outscoring them 23-0 over the final 30 minutes. QB Matthew Stafford led the way with 334 yards passing, although he didn’t throw a touchdown pass in the victory.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:46 a.m. ET.

Moneyline (ML): 49ers -350 (bet $350 to win $100) | Rams +280 (bet $100 to win $280)
Against the spread (ATS): 49ers -7.5 (-110) | Rams +7.5 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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49ers at Rams key injuries

49ers

LB Dre Greenlaw (groin) questionable
CB Samuel Womack (knee) questionable

Rams

WR Puka Nacua (oblique) questionable

49ers at Rams picks and predictions

Prediction

49ers 27, Rams 21

Moneyline

This game got a lot more interesting after the Rams blew out the Seahawks in the opener. They came into the season looking like they would struggle mightily without the stars they dumped this offseason, but played much better than expected.

That being said, the 49ers (-350) should still win this game, as they have their last 8 regular-season matchups with the Rams. They have L.A.’s number and I expect that to continue, I’m just not betting the moneyline at -350 in a rivalry game.

PASS.

Against the spread

Everything points to the 49ers covering the spread in this one. They’re the better team, they’re healthier and they’re 8-2 ATS in their last 10 games against the Rams. Yet, I find myself thinking the Rams will cover.

The offensive line is improved, the defense played better than expected and Nacua looks like the real deal as a 5th-round rookie (although his status for Sunday is unknown).

BET RAMS +7.5 (-110) to cover, but pass if this number gets down to 7.

Over/Under

The total went Under in the first game for both the Rams and 49ers this season and has cashed in 2 of the last 4 meetings between these teams.

However, the Rams’ defense isn’t as good as it seemed last week and the offense is still very capable of putting up points with Stafford, Nacua and a much-improved offensive line.

BET OVER 44.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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