The San Francisco 49ers (9-7) can ensure their spot in the postseason with a win Sunday when they visit the Los Angeles Rams (12-4) at SoFi Stadium. Kickoff in this NFC West matchup will be at 4:25 p.m. ET. Below, we look at the 49ers vs. Rams odds and lines, and make our best NFL picks, predictions and bets.
The 49ers have gone 7-3 in their last 10 games after starting the season 2-4, completely turning things around to get into position to make the playoffs. Their most recent win was a 23-7 victory over the Houston Texans in Week 17, a game that rookie QB Trey Lance started in place of the injured QB Jimmy Garoppolo.
San Francisco has played well in recent weeks, scoring at least 23 points in seven of its last eight games, and is taking on a team they’ve beaten five times in a row.
The Rams have since won five games in a row since dropping three consecutive games in November, beating the likes of the Arizona Cardinals, Minnesota Vikings and Baltimore Ravens in that stretch. The Rams still haven’t clinched the NFC West, however, with Arizona sitting just one game back in the standings, but will be crowned the division champion with a win Sunday.
49ers at Rams odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:02 a.m. ET.
- Money line: 49ers +155 (bet $100 to win $155) | Rams -190 (bet $190 to win $100)
- Against the spread (ATS): 49ers +3.5 (-112) | Rams -3.5 (-108)
- Over/Under (O/U): 44.5 (O: -110 | U: -110)
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49ers at Rams key injuries
49ers
- LT Trent Williams (elbow) questionable
- QB Jimmy Garoppolo (thumb) questionable
- CB K’Waun Williams (COVID-19) questionable
- LB Azeez Al-Shaair (knee) questionable
- LB Dre Greenlaw (groin) questionable
- S Jaquiski Tartt (shoulder) questionable
Rams
- None
Let’s Make This Interesting
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49ers at Rams odds, lines, predictions and picks
Prediction
Rams 27, 49ers 21
Money line
The 49ers have owned the Rams in the last three years. They’ve won five straight against Los Angeles since 2019, including a 31-10 victory in Week 10 of this season. However, the Rams are rolling right now and have managed to win five straight despite QB Matthew Stafford‘s turnover issues.
I like the RAMS (-190) to win outright at home with the division title on the line.
Against the spread
The 49ers are 7-3 ATS against the Rams in their last 10 meetings. They’ve owned this rivalry since Sean McVay took over as the Rams’ head coach. However, the 49ers have major injury concerns, while Los Angeles is as healthy as it’s been all year.
Take the RAMS -3.5 (-108) at almost even money to cover the spread.
Over/Under
The Over/Under is split 5-5 in the last 10 games between these teams. The Under is also 6-4 in the last 10 games for both the Rams and 49ers this season.
With San Francisco’s secondary potentially missing key pieces and the Rams offense moving the ball well — aside from Stafford’s turnovers — I see this game going OVER 44.5 (-110).
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