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The San Francisco 49ers (1-1) are visiting the LA Rams (0-2) on Sunday afternoon in a rivalry game between NFC West foes. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).
Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Rams odds, and make our expert NFL picks and predictions.
The 49ers are coming off a shocking 23-17 loss to the Minnesota Vikings in Week 2, a game in which they were 4-point road favorites. RB Christian McCaffrey remains out with Achilles tendinitis, and WR Deebo Samuel will also miss this game with a calf injury.
The Rams are 0-2 for the 1st time under coach Sean McVay, with their most recent loss being a 41-10 defeat at the hands of the Arizona Cardinals. They’re arguably the most injured team in the NFL right now, missing WRs Cooper Kupp and Puka Nacua, starting linemen Jonah Jackson and Steve Avila, as well as S John Johnson III, among others.
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49ers at Rams odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 6:54 p.m. ET.
- Moneyline (ML): 49ers -300 (bet $300 to win $100) | Rams +240 (bet $100 to win $240)
- Against the spread (ATS): 49ers -6.5 (-115) | Rams +6.5 (-105)
- Over/Under (O/U): 43.5 (O: -105 | U: -115)
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49ers at Rams key injuries
49ers
- DE Nick Bosa (rib) probable
- S Talanoa Hufanga (knee) probable
- TE George Kittle (hamstring) questionable
- RB Christian McCaffrey (Achilles) out
- WR Deebo Samuel (calf) out
- CB Charvarius Ward (hamstring/knee) questionable
- LB Dee Winters (ankle) probable
Rams
- OL Steve Avila (knee) out
- OL Kevin Dotson (foot) probable
- CB Cobie Durant (toe) probable
- OL Jonah Jackson (shoulder) out
- S John Johnson III (shoulder) out
- WR Cooper Kupp (ankle) out
- WR Puka Nacua (knee) out
- CB Darious Williams (hamstring) out
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49ers at Rams picks and predictions
Prediction
49ers 27, Rams 17
Moneyline
The 49ers are heavily favored in this game, though the ML has come down slightly to -300 after it opened at -375 on Monday. Either way, it’s not worth taking the 49ers to win outright at that number. Even with San Francisco winning 9 of the last 10 regular-season meetings against the Rams, that line is far too juiced to bet.
PASS on the ML.
Against the spread
The Rams looked completely overmatched against the Cardinals, and on paper, the 49ers are a way better team than Arizona. Injuries could be a slight concern for San Francisco in this game, but not as worrisome as the Rams’ decimated roster.
The Rams can’t stop the run and for San Francisco, that’s what’s been working best on offense with RB Jordan Mason posting back-to-back 100-yard games to open the year. The 49ers should be able to control time of possession and limit the opportunities for Los Angeles’ offense in this one.
BET 49ERS -6.5 (-115).
Over/Under
The total has dropped from 44.5 to 43.5, which is a key number. With the 49ers’ ability to run the ball and the Rams’ banged-up offense that’s missing Kupp and Nacua, this could be a lower-scoring game than we’re used to seeing from these rivals.
PASS on the total at 43.5, but if it moves back to 44.5, LEAN UNDER. The Rams could struggle to move the ball and San Francisco could shorten the game with its rushing attack.
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