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The San Francisco 49ers (5-5) and Green Bay Packers (7-3) meet Sunday in a rematch from last season’s playoffs. Kickoff from Lambeau Field is set for 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Packers odds, and make our expert NFL picks and predictions.
San Francisco lost 20-17 to the Seattle Seahawks in Week 11 while failing to cover as a 6-point favorite. The 49ers allowed a game-winning drive to the Seahawks to cap off a game where the Niners finished with over 33 minutes of possession. 49ers QB Brock Purdy will miss the game with a shoulder injury.
Green Bay narrowly escaped with a 20-19 win over the Chicago Bears Sunday while failing to cover as a 6-point favorite. The Packers blocked Chicago’s game-winning FG attempt just after QB Jordan Love rushed for a TD to put the Packers ahead.
The 49ers beat the Packers 24-21 in the NFC divisional round last season.
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49ers at Packers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:53 a.m. ET.
- Moneyline (ML): 49ers +200 (bet $100 to win $200) | Packers -250 (bet $250 to win $100)
- Against the spread (ATS): 49ers +5.5 (-110) | Packers -5.5 (-110)
- Over/Under (O/U): 44.5 (O: -110 | U: -110)
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49ers at Packers key injuries
49ers
- DL Nick Bosa (hip/oblique) out
- QB Brock Purdy (shoulder) out
- OL John Feliciano (knee) questionable
- CB Charvarious Ward (personal) out
- OT Trent Williams (ankle) questionable
Packers
- CB Jaire Alexander (knee) out
- LB Edgerrin Cooper (hamstring) out
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49ers at Packers picks and predictions
Prediction
Packers 21, 49ers 10
Moneyline
PASS.
The Packers will pick up the win here as -250 favorites and with Purdy out, but they are not worth the risk as such heavy favorites. Pass on this play and bet on the spread and/or total instead.
Against the spread
LEAN PACKERS -5.5 (-110).
Green Bay is the much healthier team and has played like the better team this season. With how San Francisco has underperformed to this point of the season, and with Purdy’s injury, the Packers should be able to cover here.
This is a lean because the Packers are 0-4 ATS in their last 4 games and because San Francisco is still a talented enough team to potentially make this a close game.
Over/Under
BET UNDER 44.5 (-110).
The Under has hit in back-to-back games for Green Bay and is 4-1-1 in the Packers’ last 6 overall. For San Francisco, the Under is also 2-0 in its last 2 overall and is 3-1 in its last 4 outings. The Under has also hit in each of the last 2 matchups between these squads.
With Purdy out, San Francisco’s offense will struggle, which will help this game stay Under 45 total points.
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