San Francisco 49ers at Cleveland Browns odds, picks and predictions

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The San Francisco 49ers (5-0) and Cleveland Browns (2-2) meet for a Week 6 matchup Sunday at Cleveland Browns Stadium. Kickoff is scheduled for 1 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook’s lines around the 49ers vs. Browns odds, and make our expert NFL picks and predictions.

The 49ers took the Dallas Cowboys behind the shed on Sunday Night Football in Week 5, winning 42-10 as 3.5-point home favorites as the Over (45) cashed. The Niners have covered 4 of 5 games overall, while cashing the Over in 3 of the past 4 outings.

San Francisco’s only game against an AFC team resulted in a 30-7 road win against the Pittsburgh Steelers in Week 1, winning as a 1-point favorite while cashing the Under (41).

The Browns are coming off a bye, and presumably that would mean a lot of the bumps and bruises have healed. However, QB Deshaun Watson is dealing with a bone bruise near the rotator cuff of his throwing shoulder, and he will miss a 2nd consecutive game. QB P.J. Walker will make the start, after rookie QB Dorian Thompson-Robinson got the nod in Week 4 prior to the bye.

Weather will be a factor in Cleveland, with the forecast showing temperatures in the mid-50’s with a 50% chance of precipitation and winds anywhere from 17-20 mph, gusting to 25-30 mph from the north-northwest right off of Lake Erie.

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49ers at Browns odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:27 p.m. ET.

Moneyline (ML): 49ers -560 (bet $560 to win $100) | Browns +420 (bet $100 to win $420)
Against the spread (ATS): 49ers -9.5 (-114) | Browns +9.5 (-106)
Over/Under (O/U): 35.5 (O: -115 | U: -105)

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49ers at Browns key injuries

49ers

LB Dre Greenlaw (hamstring) questionable
RB Elijah Mitchell (knee) questionable

Browns

OG Joel Bitonio (knee) out
TE David Njoku (face, hand) questionable
C Ethan Pocic (chest, foot, knee) questionable
WR Cedric Tillman (hip) out
QB Deshaun Watson (shoulder) out

49ers at Browns picks and predictions

Prediction

49ers 29, Browns 12

Moneyline

The 49ers (-560) will cost you more than 5½ times your potential return. While the unbeaten Niners figure to take care of the home side with a backup QB, it’s a lot of risk traveling cross-country, while playing in ugly weather conditions.

However, you’d have to be taking part in “420” to bet the Browns (+420) at this price. Cleveland is going to face a heavy dose of RB Christian McCaffrey, and Walker and the Browns are unlikely to have many answers for the suffocating defense of Frisco.

PASS.

Against the spread

The 49ERS -9.5 (-114) opened as 3.5-point favorites earlier in the week, but the money poured in at that price, then jumped dramatically upon news of the Watson situation. I don’t think Watson would impact the game greatly against this defense, especially with wet and windy conditions.

Cleveland’s run game has really struggled since RB Nick Chubb went down early in Week 2, and it hasn’t recovered. You’ll need longer cleats, and a strong run game on a slippery track, with the weather forcing the offense to the ground. San Francisco has it, Cleveland doesn’t.

Over/Under

OVER 35.5 (-115) is way too low.

Yes, both of these teams have great defenses. Yes, Watson is out, and Walker is in, but I expect the 49ers to do a lot of the heavy lifting, with CMC going wild on the ground.

The 49ers could very well take care of this number all on their own.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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