The San Francisco 49ers (2-2) and the Carolina Panthers (1-3) meet Sunday at Bank of America Stadium in Charlotte. Kickoff is scheduled for 4:05 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Panthers odds, and make our expert NFL picks and predictions.
The 49ers pasted the Rams 24-9, using their top-ranked defense to confuse and frustrate the defending champs all game long.
San Francisco ranks No. 1 with just 234.5 total yards allowed and 11.5 points allowed per game, while ranking No. 2 with 161.3 passing yards allowed and 73.3 rushing yards allowed per game.
The Panthers offense ranks dead-last in total yards per game with 262.3, and facing the 49ers’ top-ranked D isn’t the cure for their ills. Carolina is averaging just 19.5 PPG, ranking 17th in the NFL, and 2 of the team’s 4 touchdowns in the past 2 games have come on defensive scores.
Also see: All Week 5 odds and lines
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
49ers at Panthers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:45 a.m. ET.
- Moneyline (ML): 49ers -260 (bet $260 to win $100) | Panthers +215 (bet $100 to win $215)
- Against the spread (ATS): 49ers -5.5 (-115) | Panthers +5.5 (-105)
- Over/Under (O/U): 39.5 (O: -110 | U: -110)
Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!
49ers at Panthers key injuries
49ers
- DL Arik Armstead (foot, ankle) out
- RB Tyrion Davis-Price (ankle) out
- TE Tyler Kroft (knee) knee
- OT Trent Williams (ankle) out
Panthers
- LB Frankie Luvu (shoulder) questionable
- WR Laviska Shenault Jr. (hamstring) out
Play our free daily Pick’em Challenge and win! Play now!
49ers at Panthers picks and predictions
Prediction
49ers 17, Panthers 12
Moneyline
The 49ers (-260) are more than likely going to win this game, but risking nearly 3 times your potential return on a road team is risky business in the NFL. Even when something looks like a sure thing, it’s not.
PASS.
Against the spread
PANTHERS +5.5 (-105) is risky, as the offense has shown no signs of life across the first 4 games. This was expected to be an improved unit with QB Baker Mayfield, but the offense is actually worse than the 2021 team. In fact, it’s much worse.
Still, even though Carolina is facing the top-ranked 49ers -5.5 (-115) defense at home, it has a decent kicker and should be able to keep this to 1 score. The 49ers don’t exactly light the world afire on offense, either.
Over/Under
UNDER 39.5 (-110) is the best bet on the board, even though it might seem like a low number at first glance.
Remember, this is a 49ers team that went into Denver and lost 11-10. It is also a San Francisco D that has allowed 27 total points across the past 3 games. We could easily see a game that rivals the Thursday night yawner between the Indianapolis Colts and Denver Broncos. Oh, please, not again!
Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.
Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]