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The San Francisco 49ers (6-10) close out their disappointing season on the road against the Arizona Cardinals (7-9) in Week 18. Kickoff Sunday is at 4:25 p.m. ET from State Farm Stadium (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Cardinals odds, and make our expert NFL picks and predictions.
The 49ers have lost 3 games in a row and 6 of their last 7. They played on Monday night, losing 40-34 at home to the Detroit Lions, failing to cover the 3.5-point spread. The Over (50.5) cashed in.
The Cardinals have lost 5 of their 6 games since their bye. They are coming off a 13-9 road loss to the LA Rams last Saturday, covering the 6.5-point spread as underdogs. The Under (48) cashed in.
The Cardinals beat the 49ers in Santa Clara 24-23 in Week 5.
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49ers at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 12:02 a.m. ET.
- Moneyline (ML): 49ers +170 (bet $100 to win $170) | Cardinals -210 (bet $210 to win $100)
- Against the spread (ATS): 49ers +4.5 (-110) | Cardinals -4.5 (-110)
- Over/Under (O/U): 43 (O: -110 | U: -110)
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49ers at Cardinals key injuries
49ers
- DE Robert Beal Jr. (ankle) out
- S Ji’Ayir Brown (ankle) questionable
- G Spencer Burford (calf) out-IR
- LB Demetrius Flannigan-Fowles (calf) out-IR
- TE George Kittle (ankle/hamstring) questionable
- CB Deommodore Lenoir (shoulder) out
- RT Colton McKivitz (knee) questionable
- QB Brock Purdy (right elbow) out
- WR Deebo Samuel (ribs/wrist) out
- CB Isaac Yiadom (pelvis) questionable
Cardinals
- OL Jackson Barton (ankle) out-IR
- CB Sean Murphy-Bunting (toe) questionable
- K Matt Prater (knee) out
- LB Mack Wilson Sr. (ankle/quadriceps) questionable
- WR Michael Wilson (hamstring) questionable
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49ers at Cardinals picks and predictions
Prediction
Cardinals 27, 49ers 19
Moneyline
QB Josh Dobbs will get the start for the struggling Niners. They scored 34 points against the Lions, but outside of that game and their win over Chicago in Week 14, they have averaged 12.0 points per game in their last 7 games.
They are minus-11 in turnover ratio over the last 7 games, giving it away 13 times.
The Cardinals only scored 9 points in their loss to the Rams, but had nearly 400 total yards and only allowed 257 yards to the Rams.
Arizona has backup tackles playing and will have Michael Carter starting at running back, but you have to like Kyler Murray over Dobbs in the QB matchup.
The Cardinals should pick up their eighth win, but -210 odds won’t give you the value you want for your bet.
PASS.
Against the spread
The Niners’ 4 covers have all come in victories. They are 0-3 ATS as underdogs.
The Cardinals are 10-6 ATS on the season and have covered the spread in every victory.
BET CARDINALS -4.5 (-110).
Over/Under
The Niners have allowed 29 or more points in 4 of their last 6 games while Arizona scored 30 points in consecutive games before getting only 13 last week.
The last 6 meetings have all surpassed 43 points.
BET OVER 43 (-110).
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