Defending the NFC isn’t going to be an easy task for the 49ers. Their 17-game slate for the 2024 campaign features a slew of tough matchups, high-level quarterbacks and rivals both new and old.
Here’s the 49ers’ complete 2024 schedule:
| Week | Date | Opponent | Time (ET) | ||
| 1* | Sept. 9 | vs. | New York Jets | 8:15pm | Tickets |
| 2 | Sept. 15 | at | Minnesota Vikings | 1:00pm | Tickets |
| 3 | Sept. 22 | at | Los Angeles Rams | 4:25pm | Tickets |
| 4 | Sept. 29 | vs. | New England Patriots | 4:05pm | Tickets |
| 5 | Oct. 6 | vs. | Arizona Cardinals | 4:05pm | Tickets |
| 6* | Oct. 10 | at | Seattle Seahawks | 8:15pm | Tickets |
| 7 | Oct. 20 | vs. | Kansas City Chiefs | 4:25pm | Tickets |
| 8* | Oct. 27 | vs. | Dallas Cowboys | 8:20pm | Tickets |
| 9 | Nov. 3 | Bye | |||
| 10 | Nov. 10 | at | Tampa Bay Buccaneers | 1:00pm | Tickets |
| 11 | Nov. 17 | vs. | Seattle Seahawks | 4:05pm | Tickets |
| 12 | Nov. 24 | at | Green Bay Packers | 4:25pm | Tickets |
| 13* | Dec. 1 | at | Buffalo Bills | 8:20pm | Tickets |
| 14 | Dec. 8 | vs. | Chicago Bears | 4:25pm | Tickets |
| 15* | Dec. 12 | vs. | Los Angeles Rams | 8:15pm | Tickets |
| 16 | Dec. 22 | at | Miami Dolphins | 4:25pm | Tickets |
| 17* | Dec. 30 | vs. | Detroit Lions | 8:15pm | Tickets |
| 18 | TBD | at | Arizona Cardinals | TBD | Tickets |
*prime-time game