2. Week 4: Sunday, Oct. 4 at San Francisco 49ers (8:20 PM, NBC, 94WIP)
An early-season litmus test for both teams, the Eagles will travel west for a huge matchup against the defending NFC champion 49ers. San Francisco will counter with Jimmy Garoppolo, George Kittle, and Nick Bosa among a juggernaut of a team, while Philadelphia will look to solidify themselves as one of the NFC’s best early on.
A Week 4 victory in Santa Clara could catapult the Eagles towards an early lead in the division and entire NFC.