No. 4 | 2010 draft
Pick 11: OL Anthony Davis
Pick 17: OL Mike Iupati
This pair wound up being a real turning point in the 49ers’ roster makeup. Davis and Iupati wound up playing key roles in the team’s run to the NFC championship game and to the Super Bowl in their second and third seasons.
Davis started all 64 games he played in his first four years, but concussion issues pushed him into retirement in 2015 and again in 2016 after he tried to make a return. Still, he was a vital piece of a very good 49ers’ offensive front that drove them to three consecutive NFC championship games.
Iupati was with the club for all five years of his rookie contract, and he landed three Pro Bowl selections along with a First-Team All-Pro honor. Getting that kind of output from the 17th overall selection is how teams build contenders as quickly as the 49ers did in the early part of last decade.