Christian McCaffrey vs. Darius Leonard

The Panthers are a run-first team though, no matter who’s starting at quarterback. It would make sense to give Christian McCaffrey some snaps off, but Perry Fewell didn’t take him off the field last week, so it’s full steam ahead for 22. This week the guy who will have the most chances to stop him is linebacker Darius Leonard, who was a deserving Defensive Rookie of the Year last season. Leonard leads the Colts with 104 combined tackles.