The No. 5 Ohio State Buckeyes (5-1, 3-0 Big Ten) travel to meet the Indiana Hoosiers (2-4, 0-3) Saturday at Memorial Stadium in Bloomington. Kickoff is scheduled for 7:30 p.m. ET. Below, we look at the Ohio State vs. Indiana odds and lines, and make our expert college football picks, predictions and bets.
The Buckeyes have righted the ship after an early-season loss to Oregon. The defense has been better, allowing just 37 total points across the past three outings, and Ohio State has rolled up 54.5 points per game (PPG) across the past four contests.
The Hoosiers haven’t been anywhere near as effective as they were during last season’s COVID-shortened campaign. Indiana put up a good fight at “The Rock” last week, falling 20-15 to Michigan State, but it was unable to cover for a fourth straight outing.
Rankings courtesy of the AFCA Coaches Poll powered by USA Today Sports.
Ohio State at Indiana odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 6:30 a.m. ET.
- Money line: Ohio State -1200 (bet $1,200 to win $100) | Indiana +700 (bet $100 to win $700)
- Against the spread (ATS): Ohio State -20.5 (-120) | Indiana +20.5 (-105)
- Over/Under (O/U): 58.5 (O: -115 | U: -107)
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Ohio State at Indiana odds, lines, picks and predictions
Prediction
Ohio State 52, Indiana 17
Money line
Ohio State (-1200) had two weeks to prepare for this game after dusting Maryland 66-17 last time out on Oct. 9 at the ‘Shoe. This won’t end well for Indiana (+700), but you can’t lay 12 times your potential return. There’s just no value here.
AVOID.
Against the spread
OHIO STATE -20.5 (-120) is well rested and looking to put away Indiana +20.5 (-105) early with its rejuvenated offense. The Buckeyes have been scoring without much effort, and now they have had a couple of weeks to rest bumps and bruises to get back to near 100 percent. The only thing that could slow them down is rust, but that’s not really a concern.
Over/Under
OVER 58.5 (-115) is the play in this one and makes for a nice two-way parlay with Ohio State laying the points.
The Over has hit in three of the past four for Ohio State, and the Over has hit in four straight meetings while going 4-1-1 in the past six meetings in Bloomington, mostly due to the Buckeyes and their offense.
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