We have 16 games to choose players from for the last time before bye weeks begin taking anywhere from 2 to 6 teams out of play.
Below, we break down Tipico Sportsbook‘s NFL odds and lines, and tab the best NFL Week 5 player prop bets to cash in on among SportsbookWire’s NFL expert picks and predictions.
We selected 1 quarterback, 2 running backs, 1 wide receiver and 1 tight end to give you lots of options to choose from, with 2 expected to go Over their projections and 3 to go Under.
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NFL week 5 prop bet picks and predictions
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:30 a.m. ET.
Los Angeles Rams QB Matthew Stafford UNDER 256.5 passing yards (-115)
The Dallas Cowboys haven’t allowed a quarterback to throw for more than 212 yards and that list includes the Tampa Bay Buccaneers’ Tom Brady (212) and Cincinnati Bengals’ Joe Burrow (199).
While a lot of the talk around the NFL has been about the offense surviving with QB Cooper Rush, he has been a game manager. It has been the Dallas defense that has stood tall.
Stafford has only topped this number once this season (272 yards in Week 2 vs. the Atlanta Falcons) and the 5th-ranked pass defense in the league won’t make things easy on him.
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Minnesota Vikings RB Dalvin Cook OVER 78.5 rushing yards (-115)
The Chicago Bears have the worst-ranked run defense in the league (183.3 yards a game) and opponents are averaging 5.1 yards a carry.
Cook has 20 or more carries and has blown past this yardage in 3 of his last 4 meetings against the Bears, rushing for 96, 132 and 89 yards.
Cook has a strong history against the Bears when Chicago had a good rushing defense, not dead last in the league. Minnesota has figured out that the best way to beat the Bears is to give Cook the ball 20 times and the same should be expected this week.
Also see: All Week 5 odds and lines
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Pittsburgh Steelers RB Najee Harris UNDER 51.5 rushing yards (-115)
The Steelers are starting a rookie quarterback, so they will be emphasizing trying to establish the run.
However, the Bills and their 3rd ranked run defense will overload the box to prevent that and force QB Kenny Pickett to move the ball. Stopping Harris will be No. 1 defensive objective to get the Steelers in down-and-distance situations that will force their hand.
The expectation is that this is going to be a blowout — the Bills are a 14-point favorite — and, if Buffalo gets out to a big lead, the Steelers may have to abandon the run to try to keep pace.
Miami Dolphins WR Tyreek Hill OVER 67.5 receiving yards (-115)
Hill’s number is likely down because QB Tua Tagovailoa is out, but QB Teddy Bridgewater is no slouch as the backup and his receivers posted big numbers when he was with the Minnesota Vikings and Carolina Panthers.
The New York Jets have already allowed 3 100-yard receivers this season and the best part about taking the Over with Hill is that he can tack on 40 or more yards on a single play.
The Dolphins’a offense has made a concerted effort to scheme to get Hill singled up and, when he gets his hands on the ball, chunks of yards tend to follow.
Baltimore Ravens TE Mark Andrews UNDER 71.5 receiving yards (-115)
This is a big number for a tight end and Andrews has topped it twice already this season. However, the Cincinnati Bengals have historically limited his production.
In his last 5 meetings with the Bengals, he has topped 72 yards just once. Ideally, the Ravens are going to look to run the ball and the Bengals will be pinching bracket coverage around Andrews because he is the most targeted receiver the Ravens have.
To hit the Over, he will likely have to catch 6 or 7 passes and that’s a lot to ask of any tight end not named Travis Kelce.
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