NFL Betting Guide – Week 16: Odds, lines, spreads, picks and best bets

Game-by-game NFL Week 16 breakdowns, with NFL betting odds, lines, predictions, picks and betting tips for each game.

SportsbookWire’s NFL Betting Guide is at your service for Week 16; full of NFL odds, lines, spreads, game-by-game predictions, picks and best-bet selections to help you make the best NFL sports bets for the week.

With the holiday season upon us, the NFL schedule is moving around a bit. Thursday night football is replaced with three games Saturday.

Be sure to check out our top NFL Underdog Bets for Week 16, where our Ken Pomponio is 28-17 on underdog predictions with this weekly staple.

Are you looking to place a bet on any of these games? Visit BetMGM and place your bets now. Games are always more interesting when you have some skin in the game.

NFL Week 16 – Saturday, December 21, 2019

Houston Texans at Tampa Bay Buccaneers – 1:00 p.m. ET – NFL Network

Buffalo Bills at New England Patriots – 4:30 p.m. ET – NFL Network

Los Angeles Rams at San Francisco 49ers – 8:15 p.m. ET – NFL Network

NFL Week 16 – Sunday, December 22, 2019

Cincinnati Bengals at Miami Dolphins – 1:00 p.m. ET – CBS

Pittsburgh Steelers at New York Jets – 1:00 p.m. ET – CBS

New York Giants at Washington Redskins – 1:00 p.m. ET – FOX

Carolina Panthers at Indianapolis Colts – 1:00 p.m. ET – FOX – Coming soon

Baltimore Ravens at Cleveland Browns – 1:00 p.m. ET – CBS – Coming soon

Jacksonville Jaguars at Atlanta Falcons – 1:00 p.m. ET – FOX

New Orleans Saints at Tennessee Titans – 1:00 p.m. ET – FOX – Coming soon


Looking to place a bet any of the Week 16 NFL games? Get some action on the games or other sports at BetMGM. Sign up now!


Oakland Raiders at Los Angeles Chargers – 4:05 p.m. ET – CBS

Detroit Lions at Denver Broncos – 4:05 p.m. ET – CBS

Arizona Cardinals at Seattle Seahawks – 4:25 p.m. ET – FOX

Dallas Cowboys at Philadelphia Eagles – 4:25 p.m. ET – FOX

Kansas City Chiefs at Chicago Bears – 8:20 p.m. ET – NBC

NFL Week 16 – Monday, December 23, 2019

Green Bay Packers at Minnesota Vikings – 8:15 p.m. ET – ESPN – Coming soon

Now that you have the skinny on what to do with each game, visit BetMGM to place a bet on your favorite matchups now. For additional sports betting picks and tips, visit SportsbookWire.com now and for a complete set of today’s live odds, access them at USA TODAY Sports.

Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage.

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