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The Seattle Seahawks (9-8) visit the NFC West rival San Francisco 49ers (13-4) to kick off Wild Card Weekend Saturday. Kickoff from Levi’s Stadium is set for 4:30 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Seahawks vs. 49ers odds, and make our expert NFL picks and predictions.
The Seahawks made it to the postseason as the No. 7 seed in the NFC as they won their final 2 games of the season and got the help they needed from the Detroit Lions defeating the Green Bay Packers in Week 18. Seattle knocked off the New York Jets 23-6 as a 1-point underdog in Week 17 and the Los Angeles Rams 19-16 in overtime as a 5.5-point favorite to close out the regular season.
The 49ers are the hottest team in the NFL, having won their last 10 games. The last 5 wins were with rookie QB Brock Purdy, a 7th-round pick who is starting because of injuries to QBs Trey Lance and Jimmy Garoppolo. The Niners closed out the regular season with a 38-13 home win over the Arizona Cardinals as 14-point favorites.
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Seahawks at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:45 a.m. ET.
- Moneyline (ML): Seahawks +410 (bet $100 to win $410) | 49ers -525 (bet $525 to win $100)
- Against the spread (ATS): Seahawks +9.5 (-105) | 49ers -9.5 (-115)
- Over/Under (O/U): 41.5 (O: -110 | U: -110)
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Seahawks at 49ers key injuries
Seahawks
- RB DeeJay Dallas (ankle, quad) questionable
- TE Noah Fant (knee) questionable
- DL Shelby Harris (knee) questionable
- OL Phil Haynes (ankle) questionable
49ers
- QB Jimmy Garoppolo (foot) out
- CB Ambry Thomas (ankle) out
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Seahawks at 49ers picks and predictions
Prediction
49ers 27, Seahawks 10
Moneyline
The 49ers are just playing great football right now. They won both meetings with the Seahawks after losing 6 straight against them dating back to 2019.
San Francisco scored more than 30 points in 5 of its final 6 games and held opponents to 17 or fewer points in 8 of its last 10 games.
The Seahawks went 4-3 on the road but the 49ers were 8-1 at home.
The 49ers (-525) should win but there isn’t any value in wagering more than 5 times your potential return.
PASS.
Against the spread
The Niners went 2-0 ATS against the Seahawks this season. They closed the season covering the spread in 7 of their final 8 games.
The Seahawks only covered the spread once in their final 8 games.
The Seahawks are 0-5 ATS in their last 5 games against the NFC.
BET 49ERS -9.5 (-115).
Over/Under
The 49ers scored 30 points or more in 5 of their final 6 games. The Over went 5-1 in those 6 games, missing only in the game that they fell short of 30 points.
Both matchups between the 2 two teams stayed Under the projected totals, and the Under was 4-0 in the Seahawks’ final 4 games.
BET UNDER 41.5 (-110).
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