Minnesota Twins at Houston Astros odds, picks and predictions

Analyzing Wednesday’s Minnesota Twins at Houston Astros odds and lines, with MLB expert picks, predictions and best bets.

The Minnesota Twins (28-27) and Houston Astros (32-22) play the finale of a 3-game set Wednesday at Minute Maid Park. First pitch is at 8:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Twins vs. Astros odds and make our expert MLB picks and predictions for the best bets.

Season series: Twins lead 3-2

The Twins were overmatched Tuesday as the Astros evened the series at 1 with a 5-1 victory. RHP Joe Ryan allowed 5 ER over 4 innings, and that was too much to overcome for the favored Twins. Minnesota is just 4-6 and 9-11 over the last 10 and 20 games, respectively.

Houston 3B Alex Bregman had 2 hits, including a home run, and 2 RBIs Tuesday to lead the offense. The Astros scored all 5 runs in the 2nd and 3rd innings and did not tack on. Houston is 7-3 over the last 10 and 15-5 over the last 20 games as it’s starting to get healthy and fire on all cylinders.

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Twins at Astros projected starters

RHP Louie Varland vs. RHP Hunter Brown

Varland (2-1, 4.24 ERA) makes his 7th start. He has a 1.24 WHIP, 1.9 BB/9 and 9.0 K/9 in 34 innings.

  • Last start: Loss, 6 IP, 3 ER, 7 H, 0 BB, 3 K, vs. Toronto Blue Jays Friday
  • 1-0 with a 5.17 ERA, 1.47 WHIP in 3 road starts this year vs. 1-1 with a 3.44 ERA, 1.04 WHIP in 3 home starts
  • First career appearance vs. Houston

Brown (5-1, 3.12 ERA) makes his 11th start. He has a 1.20 WHIP, 2.8 BB/9 and 10.3 K/9 in 57 2/3 innings.

  • Last start: Win, 7 IP, 2 ER, 4 H, 1 BB, 10 K vs. Oakland Athletics Friday
  • 1 career start vs. Minnesota: Win, 7 IP, 0 ER, 2 H, 2 BB, 7 K in a 5-1 road win on April 9

Twins at Astros odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:18 a.m. ET.

  • Moneyline (ML): Twins +150 (bet $100 to win $150) | Astros -185 (bet $185 to win $100)
  • Run line (RL)/Against the spread (ATS): Twins +1.5 (-135) | Astros -1.5 (+110)
  • Over/Under (O/U): 8 (O: -120 | U: +100)

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Twins at Astros picks and predictions

Prediction

Astros 6, Twins 3

Moneyline

We cashed 2 of the 3 bets here Tuesday, as felt well on track for the 3rd after 5 of the 8-run total were scored in the first 3 frames before the power left the bats. There is a very large market correction here as Houston went from +100 Tuesday to -185 Wednesday.  The Twins are 3-8 in the last 11 meetings vs. Houston and 6-14 in the last 20 in Houston.

We’ll PASS on the moneyline and put together a small parlay. Brown has at least 8 K’s in his last 3 starts, and he struck out the Twins 7 times in his lone start against them. Minnesota has the highest whiff rate in baseball at 10.18 per game. So let’s go with SAME GAME PARLAY: ASTROS ML + BROWN 6+ STRIKEOUTS (-120) at a much more reasonable rate.

Run line/Against the spread

The Twins are 28-27 (14-13 on the road) on the RL, and the Astros are 28-26 (12-15 at home). Six of Houston’s 7 wins over the last 10 games have been by 2 or more runs. Houston has the advantage in the bullpen with the 3rd-best ERA at 3.07 as Minnesota sits in 8th with a 3.59 ERA.

I’ll back the ASTROS -1.5 (+110).

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Over/Under

The wind is blowing out to left-center field at 7 mph on a humid 85-degree day. Houston has scored at least 5 runs in 6 of the last 7 against the Twins and 8 of 10.

These teams have alternated Over and Under the last 6 games against one another. Tuesday went Under, so I’ll LEAN OVER 8 (-120).

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