Minnesota Twins at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Minnesota Twins at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

The Minnesota Twins (17-13) and Chicago White Sox (9-21) play the middle game of a 3-game set at Guaranteed Rate Field Wednesday. First pitch is at 7:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Twins vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The Twins fell 3-2 in 10 innings Tuesday night, wasting an awesome performance from RHP Joe Ryan, who allowed 1 hit and struck out 7 over 6 scoreless innings. The Twins managed just 3 hits in the game and are 6-4 over their last 10 games and 7-7 away from Target Field on the season.

White Sox OF Andrew Benintendi robbed a homer to save the game and then hit a walk-off single in the 10th to end it. RHP Michael Kopech was solid, aside from 5 BB, as he allowed 1 ER on 1 H with 7 K. Things won’t get any easier for the Twins Wednesday with White Sox ace RHP Dylan Cease pitching.

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Twins at White Sox projected starters

RHP Louie Varland vs. RHP Dylan Cease

Varland (0-0, 4.50 ERA) makes his 2nd start. He has a 1.17 WHIP, 1.5 BB/9 and 12.0 K/9 through 6 IP.

  • Tossed a career-high 8 K in his season debut on April 14 at the New York Yankees
  • 2 career starts vs. White Sox: 10 IP, 2 ER, 7 H, 2 BB and 8 K

Cease (2-1, 4.15 ERA) makes his 7th start. He has a 1.39 WHIP, 4.5 BB/9 and 11.0 K/9 through 30 1/3 IP.

  • Melted down in one of his worst career starts last time out against the Tampa Bay Rays Thursday: 6 ER on 9 H, 2 BB and 3 K in 4 IP
  • Last 5 starts vs. Twins: 3-2, 2.87 ERA and 34 K in 31 1/3 IP

Twins at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:47 p.m. ET.

  • Moneyline (ML): Twins +105 (bet $100 to win $105) | White Sox -125 (bet $125 to win $100)
  • Run line (RL)/Against the spread (ATS): Twins +1.5 (-190) | White Sox -1.5 (+155)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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Twins at White Sox picks and predictions

Prediction

White Sox 4, Twins 3

Moneyline

The White Sox have won 2 in a row after dropping 8 straight. They’re 2-2 against the AL Central, 2-11 against the AL East and 5-8 against everyone else. If Cease can limit the walks, he’ll be determined to put his bad last start to rest.

Take the WHITE SOX (-125).

Run line/Against the spread

Chicago is 12-18 on the RL and 5-9 straight up at home this year. Minnesota is 17-13 and 8-6 on the road. That’s the side I would lean — but we’re not going to pay -190.

I thought about going for Cease K’s here, but he has topped out at 5 K’s in his last 3 starts and it’s too volatile to handicap.

PASS.

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Over/Under

It’s a chilly 47 degrees with a 10-mph breeze coming in from left-center field. The last 3 meetings between these sides have been Under results, and the last 4 games had 7 or fewer runs. Minnesota is 14th with 4.56 runs/9, and Chicago is 22nd with 4.15 runs/9.

Those factors with Cease on the hill make me LEAN UNDER 7.5 (+100).

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