Michigan at Indiana odds, picks and predictions

Analyzing Saturday’s Michigan at Indiana odds and lines, with college football expert picks, predictions and best bets.

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The Michigan Wolverines (5-4, 3-3 Big Ten) and the No. 10 Indiana Hoosiers (9-0, 6-0) meet Saturday at Memorial Stadium in Bloomington. Kickoff is scheduled for 3:30 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s college football odds around the Michigan vs. Indiana odds, and make our expert college football picks and predictions.

Michigan dropped its third game in the last 4 outings, losing 38-17 to the No. 1 Oregon Ducks. They failed to cover the 14.5-point spread  and the Over (45) cashed. QB Davis Warren had his best showing this season, completing 12-of-21 passes for 164 yards and 2 TD with TE Colston Loveland hauling in 7 catches for 112 yards.

Indiana kept its perfect season intact with a 47-10 blowout of the Michigan State Spartans, easily covering the 7.5-point spread as the Over (53.5) hit. QB Kurtis Rourke threw for 263 yards and 4 TDs, connecting twice with WR Elijah Sarrett. Indiana’s defense stifled the Spartans, holding them to -36 rushing yards in East Lansing.

– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Michigan at Indiana odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at Friday at 6:21 a.m. ET.

  • Moneyline (ML): Michigan +450 (bet $100 to win $450) | Indiana -650 (bet $650 to win $100)
  • Against the spread (ATS): Michigan +14.5 (-115) | Indiana -14.5 (-105)
  • Over/Under (O/U): 49.5 (O: -110 | U: -110)

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Michigan at Indiana picks and predictions

Prediction

Indiana 38, Michigan 20

Moneyline

PASS.

Indiana (-650) will win this game, but I’m not going to bet $650 to win $100 in return. I’ll take my bet to the spread.

Against the spread

BET INDIANA -14.5 (-115).

It’s hard to believe Indiana is a 2-TD favorite over Michigan, but they’ve earned it. The Hoosiers have excelled against the spread in 2024, covering in 8 of 9 games overall and 4 of 5 at home. Their only ATS home loss came in Week 1, a 31-7 victory over Florida International as a 25.5-point favorite. Indiana’s offense ranks in the top 10 in average yards per game (476.2), a stark contrast to Michigan’s near-bottom standing (299.4 YPG).

Defensively, Indiana is equally impressive, with a top-10 ranking in yards allowed (72.6 per game). Meanwhile, Michigan has struggled, failing to cover in 7 of 9 games, including both road matchups. Offensive production has been a challenge for Michigan, scoring over 17 points only once in their last 4 games. Indiana’s strong all-around performance makes them clear favorites in this matchup.

Over/Under

BET OVER 49.5 (-110).

Expect a high-scoring game on Saturday, despite Indiana’s stout defense and Michigan’s woefuloffense. Michigan has scored over 30 points in each of their last 3 matchups with the Hoosiers, including 52 points in their October meeting last year.

Indiana, with its top-10 ranked offense, is capable of quick and high-scoring bursts. They’ve gone Over the point total in 2 of their last 3 home games and 7 of 8 overall. Michigan, too, has hit the Over in 5 of 6 games, allowing 21+ points in both road contests this season.

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