Miami Dolphins at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s Miami Dolphins at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

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The Miami Dolphins (8-3) visit the San Francisco 49ers (7-4) in a battle of division leaders Sunday. Kickoff from Levi’s Stadium is set for 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Dolphins vs. 49ers odds, and make our expert NFL picks and predictions.

The Dolphins have a 5-game winning streak after covering a 14-point spread in beating the Houston Texans 30-15 in Week 12. Miami had a brilliant 1st-half performance and led 30-0 at halftime and didn’t play their starters in the 2nd half. They are tied with Buffalo atop the AFC East.

The 49ers are on a 4-game winning streak since their blowout loss to the Kansas City Chiefs on Oct. 23. The NFC West leader won in Week 12 with a 13-0 shutout against the New Orleans Saints as 8-point favorites.

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Dolphins at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:24 a.m. ET.

  • Moneyline (ML): Dolphins +180 (bet $100 to win $170) | 49ers -210 (bet $210 to win $100)
  • Against the spread (ATS): Dolphins +4.5 (-109) | 49ers -4.5 (-111)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Dolphins at 49ers key injuries

Dolphins

  • OT Terron Armstead (pectoral) doubtful
  • QB Teddy Bridgewater (knee) questionable
  • RB Myles Gaskin (shoulder) questionable
  • CB Byron Jones (achilles) out

49ers

  • OT Spencer Burford (ankle) questionable
  • RB Elijah Mitchell (knee) out
  • WR Deebo Samuel (quad) questionable
  • OT Trent Williams (back) questionable

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Dolphins at 49ers picks and predictions

Prediction

49ers 38, Dolphins 35

Moneyline

PASS.

The 49ers will win this game because their defense will have the ability to not only put more pressure on the QB, but they will also be able to string together more stops. The defensive effort paired with the elite offensive playmaking ability will make this game a hard one for the Dolphins to win. But that doesn’t mean you should a bet -210 line.

Against the spread

BET DOLPHINS +4.5 (-110).

Both of these teams are very good and expected to make deep playoff runs, which is why this will be a close game. Whoever wins will do so by a field goal or less and whether it’s the 49ers or the Dolphins that win, this is your best bet.

Over/Under

LEAN OVER 45.5 (-112). 

Both of these offenses are so high powered that it is hard for me to see this game being under 46 points. The Dolphins have scored 30+ point games in 4 straight games and the 49ers have some of the most talented players in the league at every position offensively. The 49ers defense is elite, but with 2 great offenses, expect the points to flow.

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