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The No. 17 Louisville Cardinals (3-0) take on the No. 14 Notre Dame Fighting Irish (3-1) at Notre Dame Stadium Saturday. Kickoff is set for 3:30 p.m. ET (Peacock). Let’s analyze BetMGM Sportsbook’s college football odds around the Louisville vs. Notre Dame odds, and make our expert college football picks and predictions.
Louisville, or “Lull-vul”, however you pronounce it, is No. 17 in the US LBM Coaches Poll after taking down Georgia Tech 31-19 as a 9.5-point fave Sept. 21. QB Tyler Shough was 13-for-19 for 269 yards, 2 TDs and 0 INTs. The Cardinals managed just 57 yards on the ground but were able to remain efficient on offense.
The Fighting Irish, No. 14 in the US LBM Coaches Poll, failed to cover as 27-point favorites in a 28-3 laugher against Miami (Ohio) last week. QB Riley Leonard said he was going to do it himself. He went 16-for-25 for 154 yards, 1 TD and 0 INTs. He also rushed 12 times for 143 yards and 2 TDs.
– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports
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Louisville at Notre Dame odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 2:05 p.m. ET.
- Moneyline (ML): Louisville +220 (bet $100 to win $220) | Notre Dame -275 (bet $275 to win $100)
- Against the spread (ATS): Louisville +7 (-110) | Notre Dame -7 (-110)
- Over/Under (O/U): 45.5 (O: -115 | U: -105)
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Louisville at Notre Dame picks and predictions
Prediction
Notre Dame 21, Louisville 17
Moneyline
There is a lot of rain coming through the midwest from Hurricane Helene. So keep that in mind when placing bets this weekend.
Because of potentially soggy conditions, Notre Dame has a big-time advantage being at home with a better running game. Player props weren’t available at press time, and ND is too expensive.
PASS.
Against the spread
While I am confident Notre Dame wins this one, Louisville has the talent to beat it. The problem is its attack is through the air, and when weather presents itself, how is that going to translate?
I think this spread is too high, and LOUISVILLE +7 (-110) is the way to turn here.
Over/Under
Louisville is 2-1 O/U, and Notre Dame is 1-3 on the year. Notre Dame’s 1 Over cash came in a game it scored 66 points. The Under is 3-1 in the last 4 meetings between the schools, and with weather looming, there is more leverage to the UNDER 44.5 (-110).
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