Los Angeles Rams at Seattle Seahawks odds, picks and predictions

Analyzing Sunday’s Los Angeles Rams at Seattle Seahawks Week 1 odds and lines, with expert NFL picks and predictions.

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The Los Angeles Rams and Seattle Seahawks will kick off their seasons on Sunday with a Week 1 NFC West matchup at Lumen Field. Kickoff is at 4:25 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Rams vs. Seahawks odds, and make our expert NFL picks and predictions.

The Rams are coming off a dreadful 5-12 season after winning the Super Bowl 19 months ago, suffering through countless injuries and shuffling across their roster in 2022. They didn’t make many additions this offseason but they did lose several starters, including CB Jalen Ramsey, LB Bobby Wagner and LB Leonard Floyd.

The Seahawks had a surprisingly good 2022 campaign, going 9-8 with Geno Smith at quarterback in his first year with the team. Smith is back as the starter in 2023 and he’ll once again have WRs DK Metcalf and Tyler Lockett at his disposal, making this an offense that could be tough to defend.

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Rams at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:28 p.m. ET.

  • Moneyline (ML): Rams +180 (bet $100 to win $180) | Seahawks -225 (bet $225 to win $100)
  • Against the spread (ATS): Rams +4.5 (-115) | Seahawks -4.5 (-105)
  • Over/Under (O/U): 46 (O: -110 | U: -110)

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Rams at Seahawks key injuries

Rams

  • WR Cooper Kupp (hamstring) out

Seahawks

  • S Jamal Adams (knee) out
  • WR Jaxon Smith-Njigba (wrist) probable
  • CB Devon Witherspoon (hamstring) questionable

Rams at Seahawks picks and predictions

Prediction

Seahawks 30, Rams 20

Moneyline

The Seahawks (-225) are kind of heavy home favorites but this is a risky matchup as is the case with any early-season divisional game. The Rams are expected to be one of the worst teams in football but they still have QB Matthew Stafford and DL Aaron Donald, two players who have proven they can get the job done.

The moneyline isn’t worth the risk for Seattle against a Sean McVay-led team that’s 5-1 in openers since 2017, so I’m going to PASS.

Against the spread

The Rams were swept by the Seahawks last season but they managed to keep both games close. I don’t think Sunday’s matchup will be as narrow with Kupp sidelined.

The Seahawks will take care of business at home against an inexperienced defense and an offense that’s missing its only true reliable weapon.

BET SEAHAWKS -4.5 (-105).

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Over/Under

I don’t expect this game to turn into a shootout because it is Week 1 and there’s some rust to knock off, but it’s hardly going to be a defensive slugfest. The Rams will struggle to stop Seattle’s offense, both through the air and on the ground, which will in turn force Stafford to throw it more often.

I like the OVER 46 (-110).

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