The Los Angeles Rams (1-0) will be on the road in Week 2 against the Indianapolis Colts (0-1), as they visit Lucas Oil Stadium Sunday afternoon for a 1 p.m. ET kickoff. Below, we look at the Rams vs. Colts odds and lines, and make our best NFL picks, predictions and bets.
The Rams won their season opener against the Chicago Bears 34-14, making it look easy at home. QB Matthew Stafford won NFC Offensive Player of the Week, while the defense limited Chicago to only 322 total yards of offense. They look like Super Bowl contenders in the highly competitive NFC West, which started the year 4-0 in Week 1.
The Colts lost 28-16 to the Seattle Seahawks at home in Week 1. Seattle gained 381 total yards of offense, led by QB Russell Wilson and his 4 touchdown passes. QB Carson Wentz threw for 251 yards and 2 touchdowns in his Colts debut, but it wasn’t enough to lift Indy to victory.
Rams at Colts odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 3:45 p.m. ET.
- Money line: Rams -190 (bet $190 to win $100) | Colts +155 (bet $100 to win $155)
- Against the spread (ATS): Rams -3.5 (-112) | Colts +3.5 (-108)
- Over/Under (O/U): 48.5 (O: -108 | U: -112)
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Rams at Colts key injuries
Rams
- NT Sebastian Joseph-Day (knee) DNP
- DE A’Shawn Robinson (knee) limited
Colts
- LB Darius Leonard (ankle) DNP
- G Quenton Nelson (foot, back) DNP
- CB Xavier Rhodes (calf) DNP
- OT Eric Fisher (Achilles) limited
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Rams at Colts odds, lines, predictions and picks
Prediction
Rams 24, Colts 17
Money line
The Rams won their last two games against the Colts by a combined score of 84-17. Granted, those games came in 2017 and 2013, so a lot has changed since then, but Los Angeles once again has the edge in this one at just about every position.
Bet the RAMS (-190) to win outright on the road, even with it being an early 1 p.m. ET kickoff.
Against the spread
The Rams easily covered the spread in Week 1, winning by 20 points after closing as 9.5-point favorites. The Colts failed to cover while losing by 12 as 3-point underdogs.
Stafford looked great in his first game with the Rams and that was only running 50 offensive plays, so the ceiling is high for Los Angeles in Week 2 and beyond. I like the RAMS -3.5 (-112) to cover the spread Sunday.
Over/Under
The Colts scored only 16 points against the Seahawks, and the Rams defense is even better than Seattle’s. It’s reasonable to expect Indianapolis to struggle for a second straight week as Wentz continues to get comfortable in his new offense.
I like the UNDER 48.5 (-112) in this matchup between two teams with solid defenses.
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