The Los Angeles Chargers (5-5) are on the road in Week 12, visiting the Arizona Cardinals (4-7) Sunday for a 4:05 p.m. ET kickoff at State Farm Stadium in Glendale (CBS). Below, we analyze Tipico Sportsbook’s lines around the Cardinals vs. Chargers odds, and make our expert NFL picks and predictions.
The Chargers have lost 2 straight games, recently suffering a 30-27 defeat at the Kansas City Chiefs. However, they covered as 5.5-point underdogs for a 3rd consecutive cover in a row.
The Cardinals lost 38-10 to the San Francisco 49ers in Mexico City Monday night as 10-point underdogs. They have lost 3 of their last 4 games, including going 1-3 against the spread (ATS) in that span.
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Chargers at Cardinals odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 8:05 p.m. ET.
- Moneyline (ML): Chargers -150 (bet $150 to win $100) | Cardinals +125 (bet $100 to win $125)
- Against the spread: Chargers -3 (-103) | Cardinals +3 (-117)
- Over/Under (O/U): 49 (O: -109 | U: -111)
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Chargers at Cardinals key injuries
Chargers
- S Nasir Adderley (thumb) doubtful
- CB Michael Davis (knee) questionable
- WR Mike Williams (ankle) out
Cardinals
- WR Greg Dortch (thumb) questionable
- TE Zach Ertz (knee) out
- OL D.J. Humphries (back) out
- WR Rondale Moore (groin) out
- CB Byron Murphy (back) out
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Chargers at Cardinals picks and predictions
Prediction
Cardinals 28, Chargers 24
Moneyline
Even though Arizona is coming off a big loss, this game matches up well for the Cardinals.
They are at their best offensively when they can run the ball and the Chargers are 30th in the league in rushing yards allowed (148.4 yards per game) and 32nd in yards per carry allowed (5.5 YPC). The Cardinals run be ball better when QB Kyler Murray is playing, and he returns after a 2-game absence.
The Chargers also struggle to run the ball on offense. They have reached 100 yards as a team only twice all season.
Arizona is 4-0 when opponents fail to rush for 100 yards and 0-7 when they reach the century mark.
BET CARDINALS (+125).
Against the spread
The Chargers are 7-3 ATS and have covered the spread in each of their last 3 games.
The Cardinals are 5-6 ATS, including the covering the spread just once in their 7 losses.
Considering the above stat about the running game, if you like the Cardinals to win, you should bet the moneyline instead of the spread.
PASS on the spread since we’re on the Cardinals ML.
Over/Under
The Over has hit in the Cardinals’ last 5 games. They are 6-5 O/U on the season. Before their loss to the 49ers Monday, the Cardinals had averaged 29.0 PPG in 4games prior.
The Over is 5-5 in Chargers games this season.
BET OVER 49 (-109).
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