Los Angeles Angels at St. Louis Cardinals odds, picks and predictions

Analyzing Wednesday’s Los Angeles Angels at St. Louis Cardinals odds and lines, with MLB expert picks, predictions and best bets.

The Los Angeles Angels (16-14) will play the 2nd game of a 3-game series against the St. Louis Cardinals (10-20) on Wednesday at Busch Stadium. First pitch is scheduled for 7:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Angels vs. Cardinals odds and make our expert MLB picks and predictions for the best bets.

Season series: Angels lead 1-0

The Angels secured a 5-1 victory over the Cardinals on Tuesday, scoring 4 runs in the 1st inning. Los Angeles has won 5 of its last 7 games and 6 of its last 10.

Only 4 Cardinals got a hit Tuesday. St. Louis is amid a 4-game losing skid and has lost 8 of its last 10 contests.

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Angels at Cardinals projected starters

RHP Shohei Ohtani vs. RHP Miles Mikolas

Ohtani (4-0, 1.85 ERA) makes his 7th start. He has a 0.82 WHIP, 4.5 BB/9 and 12.2 K/9 through 34 IP.

  • Allowed a combined 2 ER on 8 H with 15 BB and 38 K in 28 IP in his first 5 starts
  • Gave up 5 ER on 3 H with 2 BB and 8 K in 6 IP but was credited with the win vs. the Oakland Athletics Thursday

Mikolas (1-1, 5.97 ERA) makes his 7th start. He has a 1.71 WHIP, 2.6 BB/9 and 8.2 K/9 through 31 2/3 IP.

  • His last start vs. the San Francisco Giants Thursday was his 1st start this season where he didn’t allow multiple ER as he tossed 6 1/3 scoreless innings
  • Has 4 starts this season where he’s given up 7-plus hits and he’s surrendered 6 HR thus far

Angels at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:30 a.m. ET.

  • Moneyline (ML): Angels -145 (bet $145 to win $100) | Cardinals +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Angels -1.5 (+115) | Cardinals +1.5 (-140)
  • Over/Under (O/U): 7.5 (O: -120 | U: +100)

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Angels at Cardinals picks and predictions

Prediction

Angels 5, Cardinals 2

Moneyline

BET ANGELS (-145).

Ohtani is on the mound for the Angels and the Cardinals have a struggling Mikolas on the bump. St. Louis is only 5-9 at home this season compared to Los Angeles being 8-9 on the road.

Run line/Against the spread

ANGELS -1.5 (+115) is a nice value at plus money, especially with Ohtani pitching. Ohtani has allowed multiple ER in only 1 start this season while Mikolas has only 1 start where he hasn’t given up multiple ER.

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Over/Under

UNDER 7.5 (+100) is the lean in this matchup as it’ll likely take plenty of runs from the Angels to hit the Over. The Under is 6-0-1 in Ohtani’s last 7 road starts against a team with a losing record and the Cardinals are 6-2 to the Under in their last 8 games.

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