The Kansas City Chiefs (1-0) visit the Arizona Cardinals (1-0) Friday for an 8 p.m. ET kickoff at State Farm Stadium. Below, we look at the Chiefs vs. Cardinals odds and lines and make our best NFL picks, predictions, and bets.
The Chiefs will play their starters for about a half Friday, according to head coach Andy Reid, as QB Patrick Mahomes looks to get even more comfortable with his retooled offensive line after logging about a quarter’s worth of action against the San Francisco 49ers last week.
Arizona is expected to give QB Kyler Murray his first game action of the preseason after the star quarterback sat out the opener. The Cardinals upgraded the offense during the offseason with the additions of RB James Conner and WR A.J. Green.
Chiefs at Cardinals odds, spread, and lines
Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 4:40 p.m. ET.
- Money line: Chiefs -190 (bet $190 to win $100) | Cardinals +155 (bet $100 to win $155)
- Against the spread/ATS: Chiefs -3.5 (-105) | Cardinals +3.5 (-115)
- Total: 40.5 (O: -115 | U: -105)
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Chiefs at Cardinals odds, lines, predictions and picks
Prediction
Chiefs 21, Cardinals 20
Money line
Bet on the CHIEFS (-190) Reid will have his offense on the field for the entire first half.
Mahomes should thrive behind OT Orlando Brown and G Joe Thuney during the regular season and Friday night offers the first glimpse of the retooled Kansas City offensive front.
Against the spread
PASS on the Chiefs -3.5 (-105), as Reid is only 39-39-4 ATS in the preseason.
Kansas City’s high-powered offense should get the Chiefs out to an early lead before giving way to the reserves and roster bubble guys for the second half. Arizona could make things close in the end.
Over/Under
Bet on the OVER 40.5 (-115) as both teams are capable of putting points on the board in a hurry.
For Kansas City, WR Tyreek Hill, TE Travis Kelce, RB Clyde Edwards-Helaire and the retooled offensive line will all see extended time against an Arizona defense that will be without DE J.J. Watt.
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